Clare McCann

Search results

• 2021

  Genomic reconstruction of the SARS-CoV-2 epidemic in England

  The Wellcome Sanger Institute Covid-19 Surveillance Team, The COVID-19 Genomics UK (COG-UK) Consortium, Vöhringer, H. S., Sanderson, T., Sinnott, M., De Maio, N., Nguyen, V. T. T., Goater, R., Schwach, F., Harrison, I., Hellewell, J., Ariani, C. V., Gonçalves, S., Jackson, D. K., Johnston, I., Jung, A. W., Saint, C., Sillitoe, J., Suciu, M. & Goldman, N. & 14 others, Panovska-Griffiths, J., Birney, E., Volz, E., Funk, S., Kwiatkowski, D. P., Chand, M., Martincorena, I., Barrett, J. C., Gerstung, M., Bashton, M., Nelson, A., McCann, C., Smith, D. & Young, G., 16 Dec 2021, In: Nature. 600, 7889, p. 506-511 6 p.

  Research output: Contribution to journal › Article › peer-review

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  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Lineages 66%
  • COVID-19 33%
  • Evolution 16%
  • Dynamics 16%
  58 Citations (Scopus)

  35 Downloads (Pure)

• Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management

  Page, A. J., Mather, A. E., Le-Viet, T., Meader, E. J., Alikhan, N. F., Kay, G. L., De Oliveira Martins, L., Aydin, A., Baker, D. J., Trotter, A. J., Rudder, S., Tedim, A. P., Kolyva, A., Stanley, R., Yasir, M., Diaz, M., Potter, W., Stuart Meadows, C., Bell, A. & Gutierrez, A. V. & 27 others, Nicholas, N. M., Adriaenssens, E. M., Swingler, T., Gilroy, R. A. J., Griffith, L., Sethi, D. K., Aggarwal, D., Brown, C. S., Davidson, R. K., Kingsley, R. A., Bedford, L., Coupland, L. J., Charles, I. G., Elumogo, N., Wain, J., Prakash, R., Webber, M. A., Louise Smith, S. J., Chand, M., Dervisevic, S., O’Grady, J., The COVID-19 Genomics UK (COG-UK) Consortium, Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 29 Jun 2021, In: Microbial genomics. 7, 6, p. 1-15 15 p., 000589.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Sample 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Lineages 62%
  • COVID-19 50%
  • Health 25%
  25 Citations (Scopus)

  21 Downloads (Pure)

• Patterns of within-host genetic diversity in SARS-CoV-2

  Tonkin-Hill, G., Martincorena, I., Amato, R., Lawson, A. R., Gerstung, M., Johnston, I., Jackson, D. K., Park, N., Lensing, S. V., Quail, M. A., Gonçalves, S., Ariani, C., Spencer Chapman, M., Hamilton, W. L., Meredith, L. W., Hall, G., Jahun, A. S., Chaudhry, Y., Hosmillo, M. & Pinckert, M. L. & 25 others, Georgana, I., Yakovleva, A., Caller, L. G., Caddy, S. L., Feltwell, T., Khokhar, F. A., Houldcroft, C. J., Curran, M. D., Parmar, S., The COVID-19 Genomics UK (COG-UK) Consortium, Alderton, A., Nelson, R., Harrison, E. M., Sillitoe, J., Bentley, S. D., Barrett, J. C., Torok, M. E., Goodfellow, I. G., Langford, C., Kwiatkowski, D., Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 13 Aug 2021, In: eLife. 10, 25 p., e66857.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Purifying Selection 100%
  • Nonsense Mutation 50%
  • RNA Editing 50%
  • Mixed Infection 50%
  • Superinfection 50%
  98 Citations (Scopus)

  26 Downloads (Pure)

• Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

  The COVID-19 Genomics UK (COG-UK) Consortium, Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 29 Jun 2021, In: eLife. 10, 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Hospital 100%
  • Infection 90%
  • COVID-19 60%
  • Severe Acute Respiratory Syndrome Coronavirus 2 40%
  • Feedback System 20%
  24 Citations (Scopus)

  14 Downloads (Pure)

• Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

  Meng, B., Kemp, S. A., Papa, G., Datir, R., Ferreira, I. A. T. M., Marelli, S., Harvey, W. T., Lytras, S., Mohamed, A., Gallo, G., Thakur, N., Collier, D. A., Mlcochova, P., The COVID-19 Genomics UK (COG-UK) Consortium, Duncan, L. M., Carabelli, A. M., Kenyon, J. C., Lever, A. M., De Marco, A. & Saliba, C. & 31 others, Culap, K., Cameroni, E., Matheson, N. J., Piccoli, L., Corti, D., James, L. C., Robertson, D. L., Bailey, D., Gupta, R. K., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Török, M. E., Saeed, K., Prieto, J. A., Jackson, D. K., Smith, D. L., Bashton, M., Nelson, A., Young, G. R., McCann, C. M. & Yew, W. C., 29 Jun 2021, In: Cell Reports. 35, 13, 24 p., 109292.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Infection 75%
  • Antibody 50%
  • Virus 50%
  • Cells 25%
  373 Citations (Scopus)

  25 Downloads (Pure)

• Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

  The COVID-19 Genomics UK (COG-UK) Consortium, the COVID-19 DeplOyed VaccinE (DOVE) Cohort Study investigators, Davis, C., Logan, N., Tyson, G., Orton, R., Harvey, W. T., Perkins, J. S., Mollett, G., Blacow, R. M., Peacock, T. P., Barclay, W. S., Cherepanov, P., Palmarini, M., Murcia, P. R., Patel, A. H., Robertson, D. L., Haughney, J., Thomson, E. C. & Willett, B. J. & 6 others, Bashton, M., Smith, D., Nelson, A., Young, G., McCann, C. & Yew, W., 2 Dec 2021, In: PLoS Pathogens. 17, 12, 15 p., e1010022.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Vaccine 100%
  • Neutralization 71%
  • Infection 57%
  • Severe Acute Respiratory Syndrome Coronavirus 2 57%
  • Serum 28%
  110 Citations (Scopus)

  19 Downloads (Pure)

• Retrospective screening of routine respiratory samples revealed undetected community transmission and missed intervention opportunities for SARS-CoV- 2 in the United Kingdom

  Chappell, J. G., Tsoleridis, T., Clark, G., Berry, L., Holmes, N., Moore, C., Carlile, M., Sang, F., Debebe, B. J., Wright, V., Irving, W. L., Thomson, B. J., Boswell, T. C. J., Willingham, I., Joseph, A., Smith, W., Khakh, M., Fleming, V. M., Lister, M. M. & Howson-Wells, H. C. & 10 others, Holmes, E. C., Loose, M. W., Ball, J. K., Patrick McClure, C., The COVID-19 Genomics UK (COG-UK) Consortium, Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 16 Jun 2021, In: Journal of General Virology. 102, 6, p. 1-11 11 p., 001595.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Virus 100%
  • SARS Coronavirus 50%
  • Polymerase Chain Reaction 25%
  • Specimen 25%
  • Case Definition 25%
  9 Citations (Scopus)

  15 Downloads (Pure)

• SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: Multicentre cohort study

  The COVID-19 Genomics UK (COG-UK) Consortium, Stirrup, O., Bashton, M., Nelson, A., McCann, C., Young, G. & Smith, D., 20 Sept 2021, In: BMJ Open Respiratory Research. 8, 1, 10 p., e001029.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intensive Care 100%
  • Mortality 83%
  • Severe Acute Respiratory Syndrome Coronavirus 2 66%
  • Patient 50%
  • Hospital 50%
  23 Citations (Scopus)

  15 Downloads (Pure)

• SARS-CoV-2 variants, spike mutations and immune escape

  Harvey, W. T., Carabelli, A. M., Jackson, B., Gupta, R. K., Thomson, E. C., Harrison, E. M., Ludden, C., Reeve, R., Rambaut, A., Peacock, S. J., Robertson, D. L., The COVID-19 Genomics UK (COG-UK) Consortium, Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 1 Jul 2021, In: Nature Reviews Microbiology. 19, 7, p. 409-424 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Mutation 83%
  • Virus 33%
  • Vaccine Efficacy 33%
  • Immunity 33%
  2349 Citations (Scopus)

  33 Downloads (Pure)

• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

  The CITIID-NIHR BioResource COVID-19 Collaboration, The COVID-19 Genomics UK (COG-UK) Consortium, Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R., Walls, A. C., Kemp S, S. A., Bassi, J., Pinto, D., Fregni, C. S., Bianchi, S., Tortorici, M. A., Bowen, J., Culap, K., Jaconi, S., Cameroni, E., Snell, G. & Pizzuto, M. S. & 26 others, Pellanda, A. F., Garzoni, C., Riva, A., Elmer, A., Kingston, N., Graves, B., McCoy, L. E., Smith, K. G. C., Bradley, J. R., Temperton, N., Lourdes Ceron-Gutierrez, L., Barcenas-Morales, G., Harvey, W., Virgin, H. W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., Gupta, R. K., Bashton, M., Young, G., McCann, C., Nelson, A. & Smith, D., 6 May 2021, In: Nature. 593, 7857, p. 136-141 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vaccine Efficacy 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Vaccine 100%
  • Mutation 66%
  • Monospecific Antibody 33%
  516 Citations (Scopus)

  19 Downloads (Pure)

• Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence

  Kraemer, M. U. G., Hill, V., Ruis, C., Dellicour, S., Bajaj, S., McCrone, J. T., Baele, G., Parag, K. V., Battle, A. L., Gutierrez, B., Jackson, B., Colquhoun, R. M., O'Toole, Á., Klein, B., Vespignani, A., Volz, E., Faria, N. R., Aanensen, D., Loman, N. J. & Du Plessis, L. & 10 others, Cauchemez, S., Rambaut, A., Scarpino, S. V., Pybus, O. G., The COVID-19 Genomics UK (COG-UK) Consortium, Bashton, M., Nelson, A., Young, G., Smith, D. & McCann, C., 20 Aug 2021, In: Science. 373, 6557, p. 889-895 7 p., eabj0113.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lineages 100%
  • Dynamics 66%
  • Polymerase Chain Reaction 66%
  • Growth Rate 66%
  • Severe Acute Respiratory Syndrome Coronavirus 2 66%
  114 Citations (Scopus)

  86 Downloads (Pure)

• The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study

  COG-UK HOCI Variant Substudy Consortium, The COVID-19 Genomics UK (COG-UK) Consortium, Boshier, F. A. T., Venturini, C., Stirrup, O., Guerra-Assunção, J. A., Alcolea-Medina, A., Becket, A. H., Byott, M., Charalampous, T., Filipe, A. D. S., Frampton, D., Glaysher, S., Khan, T., Kulasegara-Shylini, R., Kele, B., Monahan, I. M., Mollett, G., Parker, M. & Pelosi, E. & 32 others, Randell, P., Roy, S., Taylor, J. F., Weller, S. J., Wilson-Davies, E., Wade, P., Williams, R., Copas, A. J., Cutino-Moguel, T., Freemantle, N., Hayward, A. C., Holmes, A., Hughes, J., Mahungu, T. W., Nebbia, G., Nastouli, E., Partridge, D. G., Pope, C. F., Price, J. R., Robson, S. C., Saeed, K., Shin, G. Y., de Silva, T. I., Snell, L. B., Thomson, E. C., Witney, A. A., Breuer, J., Bashton, M., Nelson, A., McCann, C., Smith, D. & Young, G., 1 Dec 2021, In: Journal of Infection. 83, 6, p. 693-700 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hospital 100%
  • Patient 50%
  • Infection 50%
  • Reassurance 25%
  • Logistic Regression Analysis 25%
  11 Citations (Scopus)

  18 Downloads (Pure)

• The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

  NGS-SA, The COVID-19 Genomics UK (COG-UK) Consortium, Martin, D. P., Weaver, S., Tegally, H., San, J. E., Shank, S. D., Wilkinson, E., Lucaci, A. G., Giandhari, J., Naidoo, S., Pillay, Y., Singh, L., Lessells, R. J., Gupta, R. K., Wertheim, J. O., Nekturenko, A., Murrell, B., Harkins, G. W. & Lemey, P. & 9 others, MacLean, O. A., Robertson, D. L., de Oliveira, T., Kosakovsky Pond, S. L., Bashton, M., Nelson, A., McCann, C., Young, G. & Smith, D., 30 Sept 2021, In: Cell. 184, 20, p. 5189-5200.e7 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Virus 60%
  • Lineages 60%
  • Mutation 40%
  • Evolution 10%
  140 Citations (Scopus)

• The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

  The COVID-19 Genomics UK (COG-UK) Consortium, ISARIC4C Investigators, de Silva, T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., Shah, D., Wellington, D., Mentzer, A. J., Angyal, A., Brown, R., Parker, M. D., Ying, Z., Yao, X., Turtle, L., Dunachie, S., Bashton, M. & McCann, C. M. & 4 others, Nelson, A., Smith, D. L., Yew, W. C. & Young, G. R., 19 Nov 2021, In: iScience. 24, 11, 16 p., 103353.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epitope 100%
  • T Cell 71%
  • Severe Acute Respiratory Syndrome Coronavirus 2 57%
  • Virus Nucleocapsid 42%
  • CD8 42%
  62 Citations (Scopus)

  22 Downloads (Pure)

• Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2

  The COVID-19 Genomics UK (COG-UK) Consortium, O'Toole, Á., Kraemer, M. U. G., Hill, V., Pybus, O. G., Watts, A., Bogoch, I. I., Khan, K., Messina, J. P., Tegally, H., Lessells, R. R., Giandhari, J., Pillay, S., Tumedi, K. A., Nyepetsi, G., Kebabonye, M., Matsheka, M., Mine, M., Tokajian, S. & Hassan, H. & 36 others, Salloum, T., Merhi, G., Koweyes, J., Geoghegan, J. L., de Ligt, J., Ren, X., Storey, M., Freed, N. E., Pattabiraman, C., Prasad, P., Desai, A. S., Vasanthapuram, R., Schulz, T. F., Steinbrück, L., Stadler, T., Parisi, A., Bianco, A., García de Viedma, D., Buenestado-Serrano, S., Borges, V., Isidro, J., Duarte, S., Gomes, J. P., Zuckerman, N. S., Mandelboim, M., Mor, O., Seemann, T., Arnott, A., Draper, J., Gall, M., Rawlinson, W., Bashton, M., Smith, D., Nelson, A., Young, G. & McCann, C., 19 Sept 2021, In: Wellcome Open Research. 6, p. 1-14 14 p., 121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Surveillance 66%
  • Exercise 33%
  • Host 33%
  • Biological Product 33%
  119 Citations (Scopus)

  22 Downloads (Pure)