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PhD projects

Anti-cancer compounds
Molecules against neurodegenerative diseases
Anti-microbial chelators
Therapeutic Metal chelators

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Personal profile

Research interests

Metal chelators as therapeutic compounds, in particular in cancer, neurodegenerative diseases and as biostatic agents against microorganisms.

We focus on the design of powerful Fe(III) chelators of the hydroxypyridinone family that have been demonstrated by us and others to have activity as:

anticancer drugs, interfering with the biochemical processes involving metals (metalloenzymes, oxidative stress)

drugs against neurodegenerative diseases, preventing oxidative damage to neurons

biostatic agents, reducing the rate of growth of microorganisms.

Biography

I am an organic chemist who is designing novel powerful metal chelators, with a focus on Fe(III) that can have therapeutic applications, in particular against cancer, neurodegenerative diseases (Parkinson's Disease, Alzheimer's Disease) and as biostatic agents against micro-organisms. My molecules are based on rationale design, trying to optimise metal chelator and other functions such as cell penetration, multiple mode of action, targeting.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Teaching & Learning, PCAPL

11 Oct 200710 Oct 2008

Award Date: 10 Oct 2008

Chemistry, PhD

1 Sept 199330 Oct 1996

Award Date: 30 Oct 1996

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