Search results

• 2022

  1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease

  Bergin, J. C. J., Tan, K. K., Nelson, A. K., Amarandei, C-A., Hubscher-Bruder, V., Brandel, J., Voinarovska, V., Dejaegere, A., Stote, R. H. & Tetard, D., 28 Apr 2022, In: Molecules. 27, 9, 20 p., 2816.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-hydroxy-2(1H)-pyridinone 100%
  • nitrocatechol 85%
  • Tolcapone 82%
  • Parkinson disease 68%
  • blood-brain barrier 68%
  11 Downloads (Pure)

• Novel iron chelator SK4 demonstrates cytotoxicity in a range of tumour derived cell lines

  Abdelaal, G., Carter, A., Panagiotidis, M., Tetard, D. & Veuger, S., 23 Sep 2022, In: Frontiers in Molecular Biosciences. 9, 13 p., 1005092.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chelating Agents 80%
  • Tumor Cell Line 73%
  • Iron 60%
  • Amino Acids 16%
  • Mutation 15%
  4 Downloads (Pure)

• Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease

  Lewis, F. W., Bird, K., Navarro, J-P., El Fallah, R., Brandel, J., Hubscher-Bruder, V., Tsatsanis, A., Duce, J. A., Tetard, D., Bourne, S., Maina, M. & Pienaar, I. S., 1 Mar 2022, In: Dalton Transactions. 51, 9, p. 3590-3603 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroprotective 92%
  • Ligand 31%
  • Deferiprone 17%
  • Oxidative Stress 10%
  • Reactive Oxygen Metabolite 9%
  1 Citation (Scopus)

  3 Downloads (Pure)
• 2021

  A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma

  Kyriakou, S., Cheung, W., Mantso, T., Mitsiogianni, M., Anestopoulos, I., Veuger, S., Trafalis, D. T., Franco, R., Pappa, A., Tetard, D. & Panayiotidis, M. I., 1 Aug 2021, In: Investigational New Drugs. 39, 4, p. 971-986 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mimosine 100%
  • Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)-lHRH 96%
  • Ceramides 68%
  • Melanoma 48%
  • Sphingolipids 47%
  3 Citations (Scopus)

  143 Downloads (Pure)
• 2020

  Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma

  Kyriakou, S., Mitsiogianni, M., Mantso, T., Cheung, W., Todryk, S., Veuger, S., Pappa, A., Tetard, D. & Panagiotidis, M., 1 Jun 2020, In: Investigational New Drugs. 38, 3, p. 621-633 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mimosine 100%
  • Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)-lHRH 96%
  • Melanoma 48%
  • In Vitro Techniques 25%
  • Chelating Agents 21%
  9 Citations (Scopus)

  49 Downloads (Pure)

• Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

  Gutbier, S., Kyriakou, S., Schildknecht, S., Ückert, A. K., Brüll, M., Lewis, F., Dickens, D., Pearson, L., Elson, J. L., Michel, S., Hubscher-Bruder, V., Brandel, J., Tetard, D., Leist, M. & Pienaar, I. S., 1 Sep 2020, In: Archives of Toxicology. 94, 9, p. 3105-3123 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chelating Agents 80%
  • Dopaminergic Neurons 75%
  • Iron 60%
  • Antidote 34%
  • Neuroprotective 30%
  10 Citations (Scopus)

  9 Downloads (Pure)

• Novel 1‑hydroxypyridin‑2‑one metal chelators prevent and rescue ubiquitin proteasomal‑related neuronal injury in an in vitro model of Parkinson’s disease

  Lewis, F., Farooz, S., Elson, J., Hubscher-Bruder, V., Brandel, J., Soundararajan, M., Smith, D., Dexter, D., Tetard, D. & Pienaar, I., Mar 2020, In: Archives of Toxicology. 94, 3, p. 813-831 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lactacystin 100%
  • lactacystin 83%
  • Chelating Agents 61%
  • Ubiquitin 55%
  • Oxidative Stress 54%
  7 Citations (Scopus)

  20 Downloads (Pure)

• The influence of linkages between 1-Hydroxy-2(1H)-pyridinone Coordinating Groups and a Tris(2-aminoethyl)amine core in a novel series of synthetic Hexadentate Iron(III) Chelators on antimicrobial activity

  Workman, D. G., Hunter, M., Wang, S., Brandel, J., Hubscher, V., Dover, L. & Tetard, D., 1 Jan 2020, In: Bioorganic Chemistry. 95, 18 p., 103465.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • tris(2-aminoethyl)amine 100%
  • 1-hydroxy-2(1H)-pyridinone 99%
  • Tris(2-Aminoethyl)amine 60%
  • Chelating Agents 48%
  • Iron 36%
  9 Citations (Scopus)

  10 Downloads (Pure)
• 2017

  An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases

  Lewis, F. & Tetard, D., May 2017, Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. San Diego: Elsevier, p. 399-414

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Drug 32%
  1 Citation (Scopus)
• 2016

  Metal chelating compounds for use in treating diseases

  Tetard, D. & Lewis, F., 26 May 2016

  Research output: Patent

  • Heterocyclic Compound 100%

• Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

  Workman, D., Hunter, M., Dover, L. & Tetard, D., Jul 2016, In: Journal of Inorganic Biochemistry. 160, p. 49-58

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chelating Agents 100%
  • Anti-Infective Agents 91%
  • 1-hydroxy-2(1H)-pyridinone 87%
  • Macrocycle 82%
  • Iron 74%
  20 Citations (Scopus)

  17 Downloads (Pure)
• 2015

  Epoxidation of Strained Alkenes Catalysed by (1,2-dimethyl-4(1H)pyridinone-3-olate)2MnIIICl

  Robinson-Miller, A., Wyatt, M. & Tetard, D., Mar 2015, In: Journal of Molecular Catalysis A: Chemical. 398, p. 376-390

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • epoxidation 100%
  • Epoxidation 99%
  • Oxidants 73%
  • alkenes 73%
  • hydrogen peroxide 69%
  2 Citations (Scopus)

  19 Downloads (Pure)

• Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators

  Workman, D., Tsatsanis, A., Lewis, F., Boyle, J., Mousadoust, M., Hettiarachchi, N., Hunter, M., Peers, C., Tetard, D. & Duce, J., 13 May 2015, In: Metallomics : Integrated Biometal Science. 7, 5, p. 867-876

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oxidopamine 100%
  • Chelating Agents 96%
  • 1-hydroxy-2(1H)-pyridinone 79%
  • Isoflurophate 76%
  • Metals 74%
  34 Citations (Scopus)

  19 Downloads (Pure)
• 2012

  Metal Bleach Catalysts: US 2012/0260433 A1

  Tetard, D., Phillip, R. A., Richard, D. R. & Scot, M. G., 18 Oct 2012, Patent No. US 2012/0260433 A1, 11 Apr 2012, Priority date 11 Apr 2012, Priority No. US 201213443923 A

  Research output: Patent

  Open Access

  File

  • Catalyst 92%
  • Ligand 32%
  7 Downloads (Pure)
• 2011

  Hair Straightening Composition Comprising Urea: EP 1960056 B1

  Paul, C., Anne, T. C. & Tetard, D., 27 Apr 2011, Patent No. EP 1960056 B1, 6 Nov 2006, Priority date 6 Nov 2006, Priority No. EP 2006010714 W

  Research output: Patent

  Open Access

  File

  • hydroxides 100%
  • hairs 74%
  • urea 61%
  • ions 28%
  • water 16%
  7 Downloads (Pure)
• 2010

  Bleach Catalysts And Formulations Containing Them: CA 2333649 C

  Frederic, B., Riccardo, C., Michel, D., Jean-jacques, G., Ronald, H., Ariane, S. J. & Tetard, D., 6 Apr 2010, Patent No. CA 2333649 C, 10 Jun 1999, Priority date 10 Jun 1999, Priority No. GB 9901850 W

  Research output: Patent

  Open Access

  File

  • catalysts 100%
  • ligands 93%
  • aromatic compounds 91%
  • electrons 74%
  • ions 73%
  1 Downloads (Pure)
• 2006

  Composition And Method For Bleaching A Substrate: EP 1358309 B1

  Filippo, C. R., Delroisse, M. G. J., Ronald, H. & Tetard, D., 11 Oct 2006, Patent No. EP 1358309 B1, 22 Jan 2002, Priority date 22 Jan 2002, Priority No. EP 0200688 W

  Research output: Patent

  Open Access

  File
  3 Downloads (Pure)
• 2005

  Method Of Treating A Textile: EP 1109965 B1

  Maria, A. A. C., Filippo, C. R., Jose, D. M. G., Lucas, F. B., Jean-jacques, G., Ronald, H., Everardus, K. R., Franciscu, M. C., Johann, P. J. C., Lawrence, Q., Ton, S., Tetard, D., David, T., Laxmikant, T., Rob, T., Stefan, T. R., Marinus, V. S., Gerrit, V. D. V. & George, S. R., 1 Jun 2005, Patent No. EP 1109965 B1, 1 Sep 1999, Priority date 1 Sep 1999, Priority No. GB 9902878 W

  Research output: Patent

  Open Access

  File
  2 Downloads (Pure)
• 2004

  Bleaching Composition And Method For Bleaching Substrate: RU 2235125 C2

  Marija, A. A. K., Filippo, K. R., Zhoz, D. R. M. Z. B., Ljuka, F. B., Zhan-zhak, Z., Khage, R. D., Ehverardus, K. R., Fransisku, M. K., Jokhann, P. J. K., Lorens, K., Ton, S., Tetard, D., Dehvid, T., Laksmikant, T., Rob, T., Stefan, T. R., Marinus, V. S. & Gerrit, V. D. V., 27 Aug 2004, Patent No. RU 2235125 C2, 1 Sep 1999

  Research output: Patent

  Open Access

  • Bleaching Agent 36%
  • Electron Donor 10%
  • Ligand 10%
  • Nitrogen Atom 9%
  • Proton 7%

• Method For Processing Of Textile Articles: RU 2240391 C2

  Marija, A. A. K., Filippo, K. R., Zhoz, D. R. M. Z. B., Ljuka, F. B., Zhan-zhak, Z., Khage, R. D., Ehverardus, K. R., Fransisku, M. K., Jokhann, P. J. K., Lorens, K., Ton, S., Tetard, D., Dehvid, T., Laksmikant, T., Rob, T., Stefan, T. R., Marinus, V. S., Gerrit, V. D. V. & Dzhordzh, S. R., 20 Nov 2004, Patent No. RU 2240391 C2, 1 Sep 1999, Priority date 19 Mar 1999, Priority No. GB 9906474 A

  Research output: Patent

  Open Access

  • Textiles 100%
  • Textile Industry 17%
  • Coordination Complexes 16%
  • Oxygen 16%
  • Catalysis 13%
• 2002

  Bleach Catalyst And Composition And Method For Bleaching A Substrate: US 2002/0049148 A1

  Cornelis, A. A., Ronald, H., William, R. S. & Tetard, D., 25 Apr 2002, Patent No. US 2002/0049148 A1, 8 May 2001, Priority date 12 May 2000, Priority No. GB 0011527 A

  Research output: Patent

  Open Access

  File

  • Catalyst 38%
  • Ligand 20%
  6 Downloads (Pure)

• Composition And Method For Bleachin G A Substrate: WO 2002/077145 A1

  Filippo, C. R., Jose, D. M. G., Ronald, H. & Tetard, D., 3 Oct 2002, Patent No. WO 2002/077145 A1, 22 Jan 2002, Priority date 5 Feb 2001, Priority No. GB 0102826 A

  Research output: Patent

  Open Access

  File

  • Ligand 40%
  • Catalyst 19%
  9 Downloads (Pure)

• Ligand And Complex For Catalytically Bleaching Substrate: CN 1384837 A

  Appel, A. C. M., Hage, R. & Tetard, D., 11 Dec 2002, Patent No. CN 1384837 A, 17 Aug 2002, Priority date 29 Feb 2000, Priority No. GB 0004854 A

  Research output: Patent

  Open Access

  File
  3 Downloads (Pure)
• 1999

  Benzylic amide [2] catenanes as a novel photonic material

  Gase, T., Grando, D., Chollet, P. A., Kajzar, F., Lorin, A., Tetard, D. & Leigh, D. A., 1999, In: Proceedings of SPIE - The International Society for Optical Engineering. 3796, p. 257-266 10 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Electro-optics 100%
  • Photonics 91%
  • Amides 86%
  • [2]catenane 86%
  • Harmonic generation 85%

• Electrochemically Induced Dynamics of a Benzylic Amide [2]Catenane

  Ceroni, P., Leigh, D. A., Mottier, L., Paolucci, F., Roffia, S., Tetard, D. & Zerbetto, F., Nov 1999, In: Journal of Physical Chemistry B. 103, 46, p. 10171-10179 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amides 100%
  • [2]catenane 99%
  • Cyclic voltammetry 93%
  • Electrochemistry 92%
  • amides 82%
  22 Citations (Scopus)

• Raman and far infrared characterization of the simplest Benzylic Amide [2] Cantenane

  Zamboni, R., Muccini, M., Gebauer, W., Biscarini, F., Murgia, M., Ruani, G., Leigh, D. A., Murphy, A. & Tetard, D., 1 Jun 1999, In: Synthetic Metals. 102, 1-3, p. 1556-1557 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear magnetic resonance spectroscopy 100%
  • Amides 99%
  • Self assembly 85%
  • amides 81%
  • Monomers 77%
  1 Citation (Scopus)

• STM investigation of flexible supramolecules: Benzylic amide [2] catenanes

  Biscarini, F., Gebauer, W., Di Domenico, D., Zamboni, R., Pascual, J-I., Leigh, D. A., Murphy, A. & Tetard, D., 1 Jun 1999, In: Synthetic Metals. 102, 1-3, p. 1466-1467 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Scanning tunneling microscopy 100%
  • Amides 85%
  • [2]catenane 84%
  • amides 70%
  • Graphite 55%
  9 Citations (Scopus)

• Thin films of a benzylic amide [2] catenane as a novel versatile photonic material

  Gase, T., Grando, D., Chollet, P. A., Kajzar, F., Lorin, A., Leigh, D. A. & Tetard, D., Dec 1999, In: Molecular Crystals and Liquid Crystals Science and Technology Section B: Nonlinear Optics. 22, 1-4, p. 491-496 6 p.

  Research output: Contribution to journal › Conference article › peer-review

  • Photonics 100%
  • Amides 94%
  • [2]catenane 94%
  • Thin Films 77%
  • amides 77%
  3 Citations (Scopus)
• 1997

  Macrocyclic ethers by free radical cyclizations

  Philippon, A., Tao, J., Tétard, D., Degueil-Castaing, M. & Maillard, B., 1997, In: Synthetic Communications. 27, 15, p. 2651-2682 32 p.

  Research output: Contribution to journal › Article › peer-review

  • Radical Cyclization 77%
  • Acrylate 57%
  • Reaction Yield 26%
  10 Citations (Scopus)

• Oxidation Process Of Organic Substrates In The Presence Of Metal Complexes Of Tetra-, Penta- And Hexacoordinating Ligands, And Oxidation Catalysts Containing Them: WO 1997/018035 A1

  Laurent, F., Jean-Jacques, G., Frederic, P., Alain, R., David, T., Jean-Baptiste, V. & Alexander, N., 22 May 1997, Patent No. WO 1997/018035 A1, 15 Nov 1996

  Research output: Patent

  Open Access

  File

  • Oxidation Reaction 100%
  • Ligand 97%
  • Catalyst 92%
  • Iron Atom 51%
  • Hydrogen 22%
  2 Downloads (Pure)
• 1996

  Alkane hydroxylation reactions catalysed by binuclear manganese and iron complexes

  Tetard, D. & Verlhac, J. B., 25 Nov 1996, In: Journal of Molecular Catalysis A: Chemical. 113, 1-2, p. 223-230 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydroxylation 100%
  • Cyclohexane 80%
  • Oxidants 70%
  • Homolysis 70%
  • Manganese 65%
  20 Citations (Scopus)
• 1995

  Alkane hydroxylation by a manganese analogue of the iron core from methane monooxygenase

  Tétard, D., Rabion, A., Verlhac, J. B. & Guilhem, J., 1995, In: Journal of the Chemical Society, Chemical Communications. 5, p. 531-532 2 p.

  Research output: Contribution to journal › Article › peer-review

  • methane monooxygenase 100%
  • Hydroxylation 99%
  • Cyclohexane 85%
  • Alkanes 82%
  • tert-Butylhydroperoxide 78%
  30 Citations (Scopus)

• Synthesis of di-μ-oxo manganese(III/IV) complexes as functional models of L. Plantarum pseudo-catalase: Influence of electronic and steric factors; catalysis and kinetics of hydrogen peroxide disproportionation

  Delroisse, M., Rabion, A., Chardac, F., Tétard, D., Verlhac, J. B., Fraisse, L. & Séris, J. L., 1995, In: Journal of the Chemical Society, Chemical Communications. 9, p. 949-950 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Carrier concentration 100%
  • Catalysis 93%
  • Hydrogen peroxide 91%
  • Manganese 85%
  • Hydrogen Peroxide 71%
  29 Citations (Scopus)