Deepali Pal

EmailDEEPALI.PALNORTHUMBRIA.ACUK

Accepting PhD Students

PhD projects

1. Regenerative medicine and stem cells, human development/embryology, induced pluripotent stem cell reprogramming

2. 3D tissue engineering and non animal replacement models: organoid models of human bone marrow

3. 3D bioprinting, automated organoid engineering

4. Developing novel therapeutic strategies in children's leukemia, identifying "chemo-free" drug combinations towards Phase I trials

5. Defining the stem cell microenvironment in childhood cancers [paradigm leukemia]

Willing to speak to media

401

Citations

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18 Article
1 Letter

19 results

2022
Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias
Cantilena, S., Gasparoli, L., Pal, D., Heidenreich, O., Klusmann, J-H., Martens, J. H. A., Faille, A., Warren, A. J., Karsa, M., Pandher, R., Somers, K., Williams, O. & de Boer, J., Jun 2022, In: Clinical and Translational Medicine. 12, 6, p. 1-19 19 p., e933.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia
Tirtakusuma, R., Szoltysek, K., Milne, P., Grinev, V., Ptasinska, A., Chin, P. S., Meyer, C., Nakjang, S., Hehir-Kwa, J. Y., Williamson, D., Cauchy, P., Keane, P., Assi, S. A., Ashtiani, M., Kellaway, S. G., Imperato, M. R., Vogiatzi, F., Schweighart-James, E. K., Lin, S., Wunderlich, M., & 31 othersStutterheim, J., Komkov, A., Zerkalenkova, E., Evans, P., McNeill, H. V., Elder, A., Martínez-Soria, N., Fordham, S. E., Shi, Y., Russell, L. J., Pal, D., Smith, A. G., Kingsbury, Z., Becq, J., Eckert, C., Haas, O. A., Carey, P., Bailey, S., Skinner, R., Miakova, N., Collin, M., Bigley, V., Haniffa, M., Marschalek, R., Harrison, C. J., Cargo, C. A., Schewe, D. M., Olshanskaya, Y., Thirman, M. J., Cockerill, P. N. & Pal, D., 27 Oct 2022, In: Blood. 140, 17, p. 1875-1890 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Downloads (Pure)
hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia
Pal, D., Blair, H. J., Parker, J., Hockney, S., Beckett, M., Singh, M., Tirtakusuma, R., Nelson, R., McNeill, H., Angel, S. H., Wilson, A., Nizami, S., Nakjang, S., Sankar, S., Zhou, P., Schwab, C., Sinclair, P. B., Russell, L. J., Coxhead, J., Halsey, C., & 5 othersAllan, J. M., Harrison, C. J., Moorman, A. V., Olaf, H. & Vormoor, J., 16 Aug 2022, In: Cell Reports Medicine. 3, 8, 27 p., 100717.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

2 Downloads (Pure)
2020
Impaired Condensin Complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL
Molina, O., Vinyoles, M., Granada, I., Roca-Ho, H., Gutierrez-Agüera, F., Valledor, L., López-López, C. M., Rodríguez-González, P., Trincado, J. L., Tirados-Menéndez, S., Pal, D., Ballerini, P., Den Boer, M. L., Plensa, I., Perez-Iribarne, M. D. M., Rodriguez-Perales, S., Calasanz, M. J., Ramírez, M., Rodríguez, R., Camos, M., & 3 othersCalvo, M., Bueno, C. & Menendez, P., 16 Jul 2020, In: Blood. 136, 3, p. 313-327 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Citations (Scopus)

5 Downloads (Pure)
2019
Reactive jet impingement bioprinting of high cell density gels for bone microtissue fabrication
da Conceicao Ribeiro, R., Pal, D., Ferreira, A. M., Gentile, P., Benning, M. & Dalgarno, K., 1 Jan 2019, In: Biofabrication. 11, 1, 015014.
Research output: Contribution to journal › Article › peer-review

Open Access
13 Citations (Scopus)
Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia
Fidyt, K., Pastorczak, A., Goral, A., Szczygiel, K., Fendler, W., Muchowicz, A., Bartlomiejczyk, M. A., Madzio, J., Cyran, J., Graczyk-Jarzynka, A., Jansen, E., Patkowska, E., Lech-Maranda, E., Pal, D., Blair, H., Burdzinska, A., Pedzisz, P., Glodkowska-Mrowka, E., Demkow, U., Gawle-Krawczyk, K., & 7 othersMatysiak, M., Winiarska, M., Juszczynski, P., Mlynarski, W., Heidenreich, O., Golab, J. & Firczuk, M., May 2019, In: Molecular Oncology. 13, 5, p. 1180-1195 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Citations (Scopus)

21 Downloads (Pure)
2018
Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis
Carr-Wilkinson, J., Prathalingam, N., Pal, D., Moad, M., Lee, N., Sundaresh, A., Forgham, H., James, P., Herbert, M., Lako, M. & Tweddle, D. A., 1 Nov 2018, In: Stem Cells International. 2018, 12 p., 4391641.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

7 Downloads (Pure)
Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase
Fordham, S. E., Blair, H. J., Elstob, C. J., Plummer, R., Drew, Y., Curtin, N. J., Heidenreich, O., Pal, D., Jamieson, D., Park, C., Pollard, J., Fields, S., Milne, P., Jackson, G. H., Marr, H. J., Menne, T., Jones, G. L. & Allan, J. M., 22 May 2018, In: Blood. 2, 10, p. 1157-1169 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Citations (Scopus)

12 Downloads (Pure)
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
Martinez-Soria, N., McKenzie, L., Draper, J., Ptasinska, A., Issa, H., Potluri, S., Blair, H. J., Pickin, A., Isa, A., Chin, P. S., Tirtakusuma, R., Coleman, D., Nakjang, S., Assi, S., Forster, V., Reza, M., Law, E., Berry, P., Mueller, D., Elder, A., & 10 othersBomken, S. N., Pal, D., Allan, J. M., Veal, G. J., Cockerill, P. N., Wichmann, C., Vormoor, J., Lacaud, G., Bonifer, C. & Heidenreich, O., 8 Oct 2018, In: Cancer Cell. 34, 4, p. 626-642.e8 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
52 Citations (Scopus)

8 Downloads (Pure)
2017
Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia
Elder, A., Bomken, S., Wilson, I., Blair, H. J., Cockell, S., Ponthan, F., Dormon, K., Pal, D., Heidenreich, O. & Vormoor, J., Dec 2017, In: Leukemia. 31, 12, p. 2577-2586 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
22 Citations (Scopus)

6 Downloads (Pure)
Temporary Single-Cell Coating for Bioprocessing with a Cationic Polymer
da Conceicao Ribeiro, R., Pal, D., Jamieson, D., Rankin, K. S., Benning, M., Dalgarno, K. W. & Ferreira, A. M., 19 Apr 2017, In: ACS applied materials & interfaces. 9, 15, p. 12967-12974 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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8 Citations (Scopus)

7 Downloads (Pure)
2016

BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance
Weiland, J., Pal, D., Case, M., Irving, J., Ponthan, F., Koschmieder, S., Heidenreich, O., Von Stackelberg, A., Eckert, C., Vormoor, J. & Elder, A., 1 Sep 2016, In: Leukemia. 30, 9, p. 1920-1923 4 p.
Research output: Contribution to journal › Letter › peer-review

Open Access
File

17 Citations (Scopus)

5 Downloads (Pure)
Dormancy Stems the Tide of Chemotherapy
Pal, D., Heidenreich, O. & Vormoor, J., 12 Dec 2016, In: Cancer Cell. 30, 6, p. 825-826 2 p.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Citations (Scopus)
Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia
Pal, D., Blair, H. J., Elder, A., Dormon, K., Rennie, K. J., Coleman, D. J. L., Weiland, J., Rankin, K. S., Filby, A., Heidenreich, O. & Vormoor, J., Aug 2016, In: Leukemia. 30, 8, p. 1691-1700 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
31 Citations (Scopus)

3 Downloads (Pure)
2013
A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells
Moad, M., Pal, D., Hepburn, A. C., Williamson, S. C., Wilson, L., Lako, M., Armstrong, L., Hayward, S. W., Franco, O. E., Cates, J. M., Fordham, S. E., Przyborski, S., Carr-Wilkinson, J., Robson, C. N. & Heer, R., Nov 2013, In: European Urology. 64, 5, p. 753-61 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
61 Citations (Scopus)

2 Downloads (Pure)
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis
Singhapol, C., Pal, D., Czapiewski, R., Porika, M., Nelson, G. & Saretzki, G. C., 9 Jan 2013, In: PLoS One. 8, 1, 11 p., e52989.
Research output: Contribution to journal › Article › peer-review

Open Access
File
116 Citations (Scopus)

5 Downloads (Pure)
Prostate specific antigen enhances the innate defence of prostatic epithelium against Escherichia coli infection
Townes, C. L., Ali, A., Gross, N., Pal, D., Williamson, S., Heer, R., Robson, C. N., Pickard, R. S. & Hall, J., Oct 2013, In: Prostate. 73, 14, p. 1529-37 9 p.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
2012
Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptor
Williamson, S. C., Hepburn, A. C., Wilson, L., Coffey, K., Ryan-Munden, C. A., Pal, D., Leung, H. Y., Robson, C. N. & Heer, R., 7 Nov 2012, In: PLoS One. 7, 11, e48944.
Research output: Contribution to journal › Article › peer-review

Open Access
File
11 Citations (Scopus)

6 Downloads (Pure)
Secondary haemorrhage following transurethral resection of bladder tumour - is it always related to infection?
Heer, R., Glendinning, R. J., Nesbitt, C. N., Pal, D., Rix, D., Menezes, P. & Johnson, M. I., 1 Mar 2012, In: Journal of Clinical Urology. 5, 2, p. 61-66 6 p.
Research output: Contribution to journal › Article › peer-review

Deepali Pal

Research output

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