Emile Rugamika Chimusa

Search results

• 2024

  Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children

  Ginete, C., Delgadinho, M., Santos, B., Miranda, A., Silva, C., Guerreiro, P., Chimusa, E. R. & Brito, M., 8 Apr 2024, In: Genes. 15, 4, 15 p., 469.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  13 Downloads (Pure)

• Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases

  Agamah, F. E., Ederveen, T. H. A., Skelton, M., Martin, D. P., Chimusa, E. R. & 't Hoen, P. A. C., 8 Jul 2024, In: Frontiers in Molecular Biosciences. 11, 24 p., 1393240.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  4 Downloads (Pure)

• Network-based Multi-omics Disease–Drug Associations Reveal Drug Repurposing Candidates for Covid-19 Disease Phases

  Agamah, F. E., Ederveen, T. H. A., Skelton, M., Martin, D. P., Chimusa, E. R. & 't Hoen, P. A. C., 3 Jul 2024, In: Drug Repurposing. 1, 1, 22 p., e20240007.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  5 Downloads (Pure)

• Towards genomic medicine: a tailored next-generation sequencing panel for hydroxyurea pharmacogenomics in Tanzania

  Nkya, S., Nzunda, C., Saukiwa, E., Kaywanga, F., Buberwa, E., Solomon, D., Christopher, H., Ngowi, D., Johansen, J., Urio, F., Mgaya, J., Karim, S., Alimohamed, M. Z., Sangeda, R. Z., Chamba, C., Chimusa, E. R., Novelli, E. & Makani, J., 18 Jul 2024, In: BMC Medical Genomics. 17, 1, 8 p., 190.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  1 Downloads (Pure)
• 2023

  Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon

  Esoh, K. K., Apinjoh, T. O., Amambua-Ngwa, A., Nyanjom, S. G., Chimusa, E. R., Amenga-Etego, L., Wonkam, A. & Achidi, E. A., 15 Jun 2023, In: Human Molecular Genetics. 32, 12, p. 1946-1958 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SOD2 100%
  • Evolutionary Genetics 50%
  • Globin 50%
  3 Citations (Scopus)

  58 Downloads (Pure)

• Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans

  Katsukunya, J. N., Soko, N. D., Naidoo, J., Rayner, B., Blom, D., Sinxadi, P., Chimusa, E. R., Dandara, M., Dzobo, K., Jones, E. & Dandara, C., 30 May 2023, In: International Journal of Hypertension. 2023, 16 p., 9919677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  1 Citation (Scopus)

  27 Downloads (Pure)

• The African Society of Human Genetics successfully launches global data science workshops

  Nembaware, V., Bennett, D., Chimusa, E. R., Chikowore, T., Daodu, R., Bitoungui, V. N., Williams, S. M., Fatumo, S., Healy, S., Seoighe, C., Wonkam, A., The African Society of Human Genetics, Landouré, G., Ndiaye, R., Dandara, C., Mutesa, L., Ramsay, M., El-Kamah, G., Sirugo, G., Makani, J., & 16 othersSadki, K., Alimohamed, M. Z., Nkya, S., Gaye, A., Ramesar, R., Choudhury, A., Happi, C., Munung, N. S., Kherji, N., Hotchkiss, J., Ras, V., Ghansay, A., Musanabaganwa, C., Esoh, K. K., Adadey, S. M. & Coughlan, S. C., 1 Nov 2023, In: Trends in Genetics. 39, 11, p. 803-807 5 p.

  Research output: Contribution to journal › Article › peer-review

• Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes

  Thami, P. K., Choga, W. T., Dandara, C., O’Brien, S. J., Essex, M., Gaseitsiwe, S. & Chimusa, E. R., 20 Dec 2023, In: Frontiers in Genetics. 14, p. 1-15 15 p., 1290624.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  8 Downloads (Pure)
• 2022

  A whole genome sequencing approach to anterior cruciate ligament rupture–a twin study in two unrelated families

  Feldmann, D., Bope, C. D., Patricios, J., Chimusa, E. R., Collins, M. & September, A. V., 6 Oct 2022, In: PLoS One. 17, 10, 25 p., e0274354.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Anterior Cruciate Ligament 100%
  • Anterior Cruciate Ligament Rupture 69%
  • Ligament 15%
  • Tendon 15%
  • Monozygotic Twins 15%
  19 Downloads (Pure)

• Dissecting Generalizability and Actionability of Disease-Associated Genes From 20 Worldwide Ethnolinguistic Cultural Groups

  Chimusa, E. R., Alosaimi, S. & Bope, C. D., 24 Jun 2022, In: Frontiers in Genetics. 13, p. 1-12 12 p., 835713.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genes 100%
  • Diseases 70%
  • Groups 50%
  • Ethnolinguistics 40%
  • Africa 30%
  3 Citations (Scopus)

  22 Downloads (Pure)

• Dissecting Meta-Analysis in GWAS Era: Bayesian Framework for Gene/Subnetwork-Specific Meta-Analysis

  Chimusa, E. R. & Defo, J., 18 May 2022, In: Frontiers in Genetics. 13, 11 p., 838518.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meta-Analysis 100%
  • Bipolar Disorder 42%
  • Humans 28%
  • Reliability 14%
  • Methodology 14%
  4 Citations (Scopus)

  13 Downloads (Pure)

• Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury

  Feldmann, D. C., Rahim, M., Suijkerbuijk, M. A. M., Laguette, M. J. N., Cieszczyk, P., Ficek, K., Huminska-Lisowska, K., Häger, C. K., Stattin, E., Nilsson, K. G., Alvarez-Rumero, J., Eynon, N., Feller, J., Tirosh, O., Posthumus, M., Chimusa, E. R., Collins, M. & September, A. V., Jul 2022, In: Journal of Orthopaedic Research. 40, 7, p. 1604-1612 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Haplotype 100%
  • Genotyping 66%
  • Association 66%
  • Genetics 33%
  • Sample 33%
  4 Citations (Scopus)

• Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes

  Muyambo, S., Ndadza, A., Soko, N. D., Kruger, B., Kadzirange, G., Chimusa, E., Masimirembwa, C. M., Ntsekhe, M., Nhachi, C. F. B. & Dandara, C., 18 Jan 2022, In: OMICS A Journal of Integrative Biology. 26, 1, p. 35-50 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pharmacogenomics 100%
  • Warfarin 41%
  • Personalized Medicine 33%
  • Patient 25%
  • Chemotherapeutic Agent 25%
  9 Citations (Scopus)

  19 Downloads (Pure)
• 2021

  Drug response in association with pharmacogenomics and pharmacomicrobiomics: towards a better personalized medicine

  Hassan, R., Allali, I., Agamah, F. E., Elsheikh, S. S. M., Thomford, N., Dandara, C. & Chimusa, E. R., Jul 2021, In: Briefings in Bioinformatics. 14 p., bbaa292.

  Research output: Contribution to journal › Article › peer-review

  • Chemotherapeutic Agent 100%
  • Drug 100%
  • Drug Response 75%
  • Microbiome 50%
  • Personalized Medicine 50%
  15 Citations (Scopus)

• Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection

  Esoh, K. K., Apinjoh, T. O., Nyanjom, S. G., Wonkam, A., Chimusa, E. R., Amenga-Etego, L., Amambua-Ngwa, A. & Achidi, E. A., 13 Jan 2021, In: Scientific Reports. 11, 1, 13 p., 1039.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Groups 100%
  • Gene Structure 100%
  • Humans 66%
  • Genomics 66%
  • Ethnicity 66%
  2 Citations (Scopus)

  37 Downloads (Pure)

• Heritability jointly explained by host genotype and microbiome: will improve traits prediction?

  Awany, D. & Chimusa, E. R., 20 May 2021, In: Briefings in Bioinformatics. 22, 3, 12 p., bbaa175.

  Research output: Contribution to journal › Article › peer-review

  • Heritability 100%
  • Microbiome 77%
  • Wide Association Study 66%
  • Genome Wide Association Study 55%
  • Genome-Wide Association Study 55%
  5 Citations (Scopus)

• IHP-PING—generating integrated human protein–protein interaction networks on-the-fly

  Mazandu, G. K., Hooper, C., Opap, K., Makinde, F., Nembaware, V., Thomford, N. E., Chimusa, E. R., Wonkam, A. & Mulder, N. J., 20 Jul 2021, In: Briefings in Bioinformatics. 22, 4, 13 p., bbaa277.

  Research output: Contribution to journal › Article › peer-review

  • Networks 100%
  • Biological Product 100%
  • Contexts 66%
  • Database 66%
  • Online Resource 66%
  7 Citations (Scopus)

• Insilico Functional Analysis of Genome-Wide Dataset From 17,000 Individuals Identifies Candidate Malaria Resistance Genes Enriched in Malaria Pathogenic Pathways

  Damena, D., Agamah, F. E., Kimathi, P., Kabongo, N., Girma, H., Choga, W., Golassa, L. & Chimusa, E. R., 18 Nov 2021, In: Frontiers in Genetics. 12, 18 p., 676960.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nested Gene 100%
  • Genome-Wide Association Study 40%
  • Biological Functions 20%
  • Association 20%
  • Adhesion 10%
  3 Citations (Scopus)

  42 Downloads (Pure)

• Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets

  Agamah, F. E., Damena, D., Skelton, M., Ghansah, A., Mazandu, G. K. & Chimusa, E. R., Dec 2021, In: Malaria Journal. 20, 1, 20 p., 421.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Malaria 100%
  • Host 88%
  • Drug 44%
  • Diseases 33%
  • Drug Discovery 33%
  7 Citations (Scopus)

  29 Downloads (Pure)

• Profiling of warfarin pharmacokinetics‐associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics‐dosing algorithm

  Ndadza, A., Muyambo, S., Mntla, P., Wonkam, A., Chimusa, E. R., Kengne, A., Ntsekhe, M. & Dandara, C., Dec 2021, In: Journal of Thrombosis and Haemostasis. 19, 12, p. 2957-2973 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • CYP2C9 100%
  • Maintenance Drug Dose 57%
  • VKORC1 57%
  • CYP2C8 57%
  • Maintenance Dose 57%
  15 Citations (Scopus)

  16 Downloads (Pure)

• Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease

  Elsheikh, S. S. M., Chimusa, E. R., Mulder, N. & Crimi, A., 17 Dec 2021, In: Frontiers in Human Neuroscience. 15, 17 p., 761424.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • Gene Expression 33%
  • Alzheimer's Disease 22%
  • Dementia 22%
  • Gene 11%
  5 Citations (Scopus)

  18 Downloads (Pure)

• Reviewing and assessing existing meta-analysis models and tools

  Makinde, F., Tchamga, M., Jafali, J., Fatumo, S., Chimusa, E. R., Mulder, N. & Mazandu, G. K., 5 Nov 2021, In: Briefings in Bioinformatics. 22, 6, 12 p., bbab324.

  Research output: Contribution to journal › Article › peer-review

  • Meta Analysis 100%
  • Meta-Analysis 100%
  • Tools 83%
  • Procedures 66%
  • Sample Size 33%
  6 Citations (Scopus)

• Simulation of African and non-African low and high coverage whole genome sequence data to assess variant calling approaches

  Chimusa, E. R., 1 Jul 2021, In: Briefings in Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Genetic Divergence 100%
  • Accuracy 100%
  • Development 50%
  • Genetics 50%
  2 Citations (Scopus)

• Utilization of Pneumococcal Vaccine and Penicillin Prophylaxis in Sickle Cell Disease in Three African Countries: Assessment among Healthcare Providers in SickleInAfrica

  The SickleInAfrica Consortium, 6 Aug 2021, In: Hemoglobin. 45, 3, p. 163-170 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sickle Cell Anemia 100%
  • Penicillin Derivative 83%
  • Prophylaxis 66%
  • Pneumococcus Vaccine 50%
  • Infection 33%
  4 Citations (Scopus)

• Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment

  Oluwole, O., Esoh, K. K., Wonkam-Tingang, E., Manyisa, N., Noubiap, J. J., Chimusa, E. R. & Wonkam, A., 1 Jan 2021, In: Experimental Biology and Medicine. 246, 2, p. 197-206 10 p.

  Research output: Contribution to journal › Article › peer-review

  • GJB6 100%
  • GJB2 100%
  • Protein Modeling 50%
  7 Citations (Scopus)
• 2020

  A potential roadmap to overcome the current eastern DRC Ebola virus disease outbreak: From a computational perspective

  Chimusa, E. R., 1 Mar 2020, In: Scientific African. 7

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Computational/in silico methods in drug target and lead prediction

  Chimusa, E. R., 25 Sept 2020, In: Briefings in Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  • Drug 100%
  • Diseases 50%
  • Clinical Trial 25%
  • Biological Product 25%
  • Drug Discovery 25%
  141 Citations (Scopus)

• Dissecting genome-wide studies for microbiome-related metabolic diseases

  Chimusa, E. R., 15 Sept 2020, In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  • Water-Electrolyte Imbalance 100%
  • Microbiome 66%
  • Single Nucleotide Polymorphism 33%
  • Gene 33%
  • Host 33%
  1 Citation (Scopus)

• FRANC: a unified framework for multi-way local ancestry deconvolution with high density SNP data

  Chimusa, E. R., 25 Sept 2020, In: Briefings in Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  • Genomic Variation 100%
  • Ancestry Estimate 100%
  • Medical Genetics 50%
  2 Citations (Scopus)

• Genetic modifiers of long‐term survival in sickle cell anemia

  Chimusa, E. R., 12 Aug 2020, In: Clinical and Translational Medicine.

  Research output: Contribution to journal › Article › peer-review

• Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer’s Disease

  Elsheikh, S. S. M., Chimusa, E. R., Mulder, N. J. & Crimi, A., 1 Dec 2020, In: Scientific Reports. 10, 1, 1433.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  22 Citations (Scopus)

• Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance

  Chimusa, E. R., 1 Jan 2020, In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Hearing Impairment Overview in Africa: the Case of Cameroon

  Chimusa, E. R., 22 Feb 2020, In: Genes.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• High-depth African genomes inform human migration and health

  H3Africa Consortium, TrypanoGEN Research Group, Choudhury, A., Aron, S., Botigué, L. R., Sengupta, D., Botha, G., Bensellak, T., Wells, G., Kumuthini, J., Shriner, D., Fakim, Y. J., Ghoorah, A. W., Dareng, E., Odia, T., Falola, O., Adebiyi, E., Hazelhurst, S., Mazandu, G., Nyangiri, O. A., & 31 othersMbiyavanga, M., Benkahla, A., Kassim, S. K., Mulder, N., Adebamowo, S. N., Chimusa, E. R., Muzny, D., Metcalf, G., Gibbs, R. A., Matovu, E., Bucheton, B., Hertz-Fowler, C., Koffi, M., Macleod, A., Mumba-Ngoyi, D., Noyes, H., Nyangiri, O. A., Simo, G., Simuunza, M., Rotimi, C., Ramsay, M., Choudhury, A., Aron, S., Botigué, L., Sengupta, D., Botha, G., Bensellak, T., Wells, G., Kumuthini, J., Shriner, D. & Fakim, Y. J., 29 Oct 2020, In: Nature. 586, 7831, p. 741-748 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Metabolism 100%
  178 Citations (Scopus)

  19 Downloads (Pure)

• Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania

  Nkya, S., Nkya, S., Mwita, L., Mgaya, J., Kumburu, H., Van Zwetselaar, M., Menzel, S., Mazandu, G. K., Mazandu, G. K., Mazandu, G. K., Sangeda, R., Sangeda, R., Chimusa, E. & Makani, J., 5 Jun 2020, In: BMC Medical Genetics. 21, 1, 125.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fetal Hemoglobin 100%
  • Hemoglobin Variant 33%
  • HOXA9 33%
  • BCL11A 33%
  • HBG1 33%
  10 Citations (Scopus)

• Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology

  Chimusa, E. R., 7 May 2020, In: OMICS A Journal of Integrative Biology. 24, 5, p. 264-277

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon

  Wonkam, A., Manyisa, N., Bope, C. D., Dandara, C. & Chimusa, E. R., 1 Dec 2020, In: Human Molecular Genetics. 29, 23, p. 3729–3743 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene 100%
  • Hearing Loss 90%
  • Phenotype 18%
  • COL9A3 18%
  • Actin Cytoskeleton 9%
  7 Citations (Scopus)

  42 Downloads (Pure)
• 2019

  A broad survey of DNA sequence data simulation tools

  Chimusa, E. R., 23 Dec 2019, In: Briefings in Functional Genomics. p. 49-59 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Simulation Tool 100%
  • Simulation Mode 16%
  • Research Worker 16%
  • Simulation 16%
  • Generation 16%
  14 Citations (Scopus)

• A comprehensive survey of models for dissecting local ancestry deconvolution in human genome

  Chimusa, E. R., 27 Sept 2019, In: Briefings in Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  • Evolution 100%
  • Mutation 100%
  • Light 100%
  • Comprehension 100%
  • Human Genome 100%
  23 Citations (Scopus)

• An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C

  Chimusa, E. R., Jun 2019, In: Pharmacogenomics Journal.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

  Chimusa, E. R., Dec 2019, In: Translational Psychiatry.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Detecting genetic modifiers of spondyloepimetaphyseal dysplasia with joint laxity in the Caucasian Afrikaner community

  Chimusa, E. R., 1 Apr 2019, In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Dissecting in silico Mutation Prediction of Variants in African Genomes: Challenges and Perspectives

  Chimusa, E. R., 25 Jun 2019, In: Frontiers in Genetics.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Genetic diversity and drug susceptibility profiles of Mycobacterium tuberculosis obtained from Saint Peter’s TB specialized Hospital, Ethiopia

  Chimusa, E. R., 24 Jun 2019, In: PLoS One.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

  Chimusa, E. R., Dec 2019, In: BMC Medical Genomics.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• GJB2 and GJB6 Mutations in Hereditary Recessive Non-Syndromic Hearing Impairment in Cameroon

  Chimusa, E. R., 25 Oct 2019, In: Genes.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

  Chimusa, E. R., 22 Jan 2019, In: Frontiers in Genetics.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa

  Chimusa, E. R., 28 May 2019, In: Frontiers in Genetics.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Polygenic Adaptation Underlies Evolution of Brain Structures and Behavioral Traits

  Chimusa, E. R., 2019, In: European Neuropsychopharmacology.

  Research output: Contribution to journal › Article › peer-review

• Population Structure and Implications on the Genetic Architecture of HIV-1 Phenotypes Within Southern Africa

  Chimusa, E. R., 27 Sept 2019, In: Frontiers in Genetics.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)