Research output per year
Research output per year
Search results
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2024
Impact of the T296S Mutation in P450 GcoA for Ary-O-demethylation: A QM/MM study
Gomes Dos Santos, S., Bommareddy, R., Black, G. & Singh, W., 11 Jan 2024, In: Frontiers in Chemistry. 11, 8 p., 1327398.Research output: Contribution to journal › Article › peer-review
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Rational design of a cyclohexanone dehydrogenase for enhanced α,β-desaturation and substrate specificity
Singh, W., Brown, N. L., McCue, H. V., Marriott, S. R., Wilson, R. C., Perry, J., Turkenburg, J. P., Dubey, K. D., Prior, S. H., Carnell, A. J., Taylor, E. J. & Black, G. W., 7 Apr 2024, In: Chemical Science. 15, 13, p. 4969-4980 12 p.Research output: Contribution to journal › Article › peer-review
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2023
A computational approach to optimising laccase-mediated polyethylene oxidation through carbohydrate-binding module fusion
Gollan, M., Black, G. & Muñoz-Muñoz, J. L., 6 Jul 2023, In: BMC Biotechnology. 23, 1, p. 1-21 21 p., 18.Research output: Contribution to journal › Article › peer-review
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Biocatalytic and Chemo-Enzymatic Synthesis of Quinolines and 2-Quinolones by Monoamine Oxidase (MAO-N) and Horseradish Peroxidase (HRP) Biocatalysts
Xiang, H., Ferla, S., Varricchio, C., Brancale, A., Brown, N. L., Black, G. W., Turner, N. J. & Castagnolo, D., 3 Mar 2023, In: ACS Catalysis. 13, 5, p. 3370-3378 9 p.Research output: Contribution to journal › Article › peer-review
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Fungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium species
Fernández Juliá, P. J., Black, G. W., Cheung, W., Van Sinderen, D. & Munoz-Munoz, J., 30 May 2023, In: Communications Biology. 6, 1, 14 p., 576.Research output: Contribution to journal › Article › peer-review
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In Search of Complementary Extraction Methods for Comprehensive Coverage of the Escherichia coli Metabolome
Gould, H., Cheung, W., Finnigan, J. D., Muñoz-Muñoz, J., Charnock, S. J. & Black, G. W., 14 Sept 2023, In: Metabolites. 13, 9, 13 p., 1010.Research output: Contribution to journal › Article › peer-review
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Substrate Conformation Regulates Aromatic C-H Vs C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase
Singh, W., Gomes Dos Santos, S., Yadav, S., Black, G. & Dubey, K. D., 16 May 2023, In: Biochemistry. 62, 10, p. 1577-1587 11 p.Research output: Contribution to journal › Article › peer-review
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The substrate specificity in the O-demethylation of 4-alkylguaiacols by cytochrome P450 AgcAP450
Santos, S. F. G., Bommareddy, R., Black, G., Singh, W. & Huang, M., 7 Apr 2023, In: Catalysis Science and Technology. 13, 7, p. 2070-2079 10 p.Research output: Contribution to journal › Article › peer-review
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Towards a Self-sustaining Home: Circular Flows of Materials and Energy in the Domestic Environment
McLeod-Brown, P., Bridgens, B., Mackenzie, L., Modi, K., Kalathil, S., Bommareddy, R., Black, G. & Perry, O., 6 Jun 2023, Bioprotopia: Designing the Built Environment with Living Organisms. Morrow, R., Bridges, B. & Mackenzie, L. (eds.). 1st ed. Basel, Switzerland: Birkhauser, p. 130-145 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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2022
Computer-Informed Engineering: A New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of an Unusual C10-(S)-Bicyclogermacrene
Yang, X., Zhou, J., Ge, J., Li, W., Liang, D., Singh, W., Nie, S., Black, G., Liu, J., Sun, M., Qiao, J. & Huang, M., 1 Apr 2022, In: ACS Catalysis. 12, 7, p. 4037-4045 9 p., 12.Research output: Contribution to journal › Article › peer-review
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Editorial: Enzyme Biocatalysts: Design and Application
Cui, J., Zheng, G.-W., Black, G., Iqbal, H. M. N. & Bilal, M., 2 Feb 2022, In: Frontiers in Chemistry. 10, p. 1-2 2 p., 851857.Research output: Contribution to journal › Editorial › peer-review
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Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA
Singh, W., Santos, S., Black, G., James, P., Huang, M. & Dubey, K. D., 21 Jun 2022, In: ACS Omega. 7, 24, p. 21109–21118 10 p.Research output: Contribution to journal › Article › peer-review
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2020
Monoamine Oxidase (MAO-N) Biocatalyzed Synthesis of Indoles from Indolines Prepared via Photocatalytic Cyclization/Arylative Dearomatization
Zhao, F., Masci, D., Ferla, S., Varricchio, C., Brancale, A., Colonna, S., Black, G., Turner, N. & Castagnolo, D., 5 Jun 2020, In: ACS Catalysis. 10, 11, p. 6414–6421 8 p.Research output: Contribution to journal › Article › peer-review
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2019
A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution
Lauder, K., Masci, D., Toscani, A., Al Mekdad, A., Black, G., Brown, N., Turner, N. J., Luisi, R. & Castagnolo, D., 28 Oct 2019, In: Organic and Biomolecular Chemistry. 17, 40, p. 8982-8986 5 p.Research output: Contribution to journal › Article › peer-review
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Proteomics and bioinformatics analyses identify novel cellular roles outside mitochondrial function for human miro GTPases
Kay, L. J., Sangal, V., Black, G. W. & Soundararajan, M., 1 Jan 2019, In: Molecular and Cellular Biochemistry. 451, 1-2, p. 21-35 15 p.Research output: Contribution to journal › Article › peer-review
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2018
Antidiabetic "gliptins" affect biofilm formation by Streptococcus mutans
De, A., Pompilio, A., Francis, J., Sutcliffe, I. C., Black, G. W., Lupidi, G., Petrelli, D. & Vitali, L. A., 1 Apr 2018, In: Microbiological Research. 209, p. 79-85 7 p.Research output: Contribution to journal › Article › peer-review
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Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis
Thai, Y.-C., Szekrenyi, A., Qi, Y., Black, G., Charnock, S. & Fessner, W.-D., 1 Apr 2018, In: Bioorganic & Medicinal Chemistry. 26, 7, p. 1320-1326Research output: Contribution to journal › Article › peer-review
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Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines
Toscani, A., Risi, C., Black, G. W., Brown, N. L., Shaaban, A., Turner, N. J. & Castagnolo, D., 7 Sept 2018, In: ACS Catalysis. 8, 9, p. 8781-8787 7 p.Research output: Contribution to journal › Article › peer-review
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Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase
Ainsley, J., Mulholland, A. J., Black, G. W., Sparagano, O., Christov, C. Z. & Karabencheva-christova, T. G., 31 May 2018, In: ACS Omega. 3, 5, p. 4847-4859Research output: Contribution to journal › Article › peer-review
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Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders
Kay, L., Pienaar, I. S., Cooray, R., Black, G. & Soundararajan, M., 1 Sept 2018, In: Molecular Neurobiology. 55, 9, p. 7352-7365 14 p.Research output: Contribution to journal › Review article › peer-review
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2017
The effect of Maillard reaction products and yeast strain on the synthesis of key higher alcohols and esters in beer fermentations
Dack, R., Black, G., Koutsidis, G. & Usher, S. J., 1 Oct 2017, In: Food Chemistry. 232, p. 595-601Research output: Contribution to journal › Article › peer-review
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Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles
Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In: ACS Catalysis. 7, 2, p. 1295-1300 6 p.Research output: Contribution to journal › Article › peer-review
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2016
Conformational dynamics, ligand binding and effects of mutations in NirE an S-adenosyl-L-methionine dependent Methyltransferase
Singh, W., Karabencheva-Christova, T., Black, G., Ainsley, J., Dover, L. & Christov, C., 1 Apr 2016, In: Scientific Reports. 6, 20107.Research output: Contribution to journal › Article › peer-review
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Conformational flexibility influences structure–function relationships in tyrosyl protein sulfotransferase-2
Singh, W., Karabencheva-Christova, T., Black, G., Sparagano, O. & Christov, C., 2016, In: RSC Advances. 6, 14, p. 11344-11352Research output: Contribution to journal › Article › peer-review
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Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application
Cook, D., Finnigan, J., Cook, K., Black, G. & Charnock, S. J., 9 Aug 2016, (E-pub ahead of print) Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods. Christov, C. (ed.). London: Elsevier, Vol. 105. p. 105-126Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access -
Dimerization and ligand binding in tyrosylprotein sulfotransferase-2 are influenced by molecular motions
Singh, W., Karabencheva-Christova, T., Sparagano, O., Black, G., Petrov, P. & Christov, C., 2016, In: RSC Advances. 6, 22, p. 18542-18548Research output: Contribution to journal › Article › peer-review
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Label-free Quantitative Proteomic Analysis of Proteins Essential for Bacterial Growth on Biomass
Porter, A., Lavery, P., Wells, M., Borthwick, A., Dover, L., Zhang, M. & Black, G., 2016, Nonlinear Dynamics ltd.Research output: Other contribution
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Proteomic Analysis of Cellvibrio japonicus UEDA 107 using Gas Phase Fractionation and 2D Gel Electrophoresis
Porter, A., Lavery, P., Dover, L., Zhang, M. & Black, G., 2016, Nonlinear Dynamics ltd.Research output: Other contribution
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2015
A high-throughput screening method for determining the substrate scope of nitrilases
Black, G., Brown, N., Perry, J., Randall, P. D., Turnbull, G. & Zhang, M., 9 Jan 2015, In: Chemical Communications. 51, p. 2660-2662Research output: Contribution to journal › Article › peer-review
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An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain
Wilding, B., Veselá, A., Perry, J., Black, G., Zhang, M., Martínková, L. & Klempier, N., Jun 2015, In: Organic & Biomolecular Chemistry. 13, 28, p. 7803-7812Research output: Contribution to journal › Article › peer-review
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Characterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substrates
Ikolo, F., Zhang, M., Harrington, D., Robinson, C., Waller, A., Sutcliffe, I. & Black, G., 1 Dec 2015, In: Molecular BioSystems. 11, p. 3279-3286Research output: Contribution to journal › Article › peer-review
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2014
Changes in immunoreactive terminals containing serotonin, substance P, vesicular glutamate transporter 2 and corticotropin-releasing factor in the lumbosacral spinal cord of aged C56BL/6J male mice
Tsang, H., Zhang, M., Black, G., Saffrey, M. J. & Ranson, R., 7 Jul 2014.Research output: Contribution to conference › Poster
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How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?
Karabencheva-Christova, T., Lee, C., Black, G., Donev, R. & Christov, C., 1 Jun 2014, In: Molecular BioSystems. 10, p. 1490-1495Research output: Contribution to journal › Article › peer-review
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2013
Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study
Karabencheva-Christova, T., Carlsson, U., Balali-Mood, K., Black, G. & Christov, C., 25 Feb 2013, In: PLoS One. 8, 2, p. e56874Research output: Contribution to journal › Article › peer-review
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Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone
Malik, V., Zhang, M., Dover, L. G., Northen, J. S., Flinn, A., Perry, J. J. & Black, G. W., 30 Aug 2013, In: Molecular BioSystems. 9, 11, p. 2816-2822 7 p.Research output: Contribution to journal › Article › peer-review
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2012
Structural, functional, and mutagenesis studies of UDP-glycosyltransferases
Malik, V. & Black, G., 2012, In: Advances in Protein Chemistry and Structural Biology. 87, p. 87-115Research output: Contribution to journal › Article › peer-review
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The impact of pH and nutrient stress on the growth and survival of Streptococcus agalactiae
Yang, Q., Porter, A., Zhang, M., Harrington, D., Black, G. & Sutcliffe, I., Aug 2012, In: Antonie van Leeuwenhoek. 102, 2, p. 277-287Research output: Contribution to journal › Article › peer-review
Open Access -
2011
A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminase
Yang, Q., Zhang, M., Harrington, D., Black, G. & Sutcliffe, I., Aug 2011, In: Microbes and Infection. 13, 8-9, p. 757-760Research output: Contribution to journal › Article › peer-review
Open Access -
Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations
Elmabrouk, Z., Vincent, F., Zhang, M., Smith, N. L., Turkenburg, J., Charnock, S., Black, G. & Taylor, E., Mar 2011, In: Proteins: Structure, Function, and Bioinformatics. 79, 3, p. 965-974Research output: Contribution to journal › Article › peer-review
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Probing the enantioselectivity of a diverse group of purified cobalt-centred nitrile hydratases
van Pelt, S., Zhang, M., Otten, L., Holt, J., Sorokin, D., van Rantwijk, F., Black, G., Perry, J. & Sheldon, R., 2011, In: Organic and Biomolecular Chemistry. 9, 8, p. 3011-3019Research output: Contribution to journal › Article › peer-review
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2010
A proteomic investigation of Streptococcus agalactiae grown under conditions associated with neonatal exposure reveals the upregulation of the putative virulence factor C protein β antigen
Yang, Q., Zhang, M., Harrington, D., Black, G. & Sutcliffe, I., Jun 2010, In: International Journal of Medical Microbiology. 300, 5, p. 331-337Research output: Contribution to journal › Article › peer-review
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Biotransformation of nitriles using the solvent-tolerant nitrile hydratase from Rhodopseudomonas palustris CGA009
Black, G., Gregson, T., McPake, C., Perry, J. & Zhang, M., Mar 2010, In: Tetrahedron Letters. 51, 13, p. 1639-1641Research output: Contribution to journal › Article › peer-review
Open Access -
2009
Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1
Martinez-Fleites, C., Smith, N. L., Turkenburg, J., Black, G. & Taylor, E., 2009, In: Acta Crystallographica Section F:Structural Biology Communications. 65, 10, p. 963-966Research output: Contribution to journal › Article › peer-review
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The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection
Black, A., Zhang, M., Mitchell, Z., Holden, M. T. G., Waller, A., Sutcliffe, I. C. & Black, G. W., 1 Feb 2009, In: Microbiology. 155, 2, p. 443-449 7 p.Research output: Contribution to journal › Article › peer-review
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2008
Bioinformatic insights into the biosynthesis of the Group B carbohydrate in Streptococcus agalactiae
Sutcliffe, I., Black, G. & Harrington, D., 2008, In: Microbiology. 154, 5, p. 1354-1363Research output: Contribution to journal › Article › peer-review
Open Access -
2007
Group A streptococcus cell-associated pathogenic proteins as revealed by growth in hyaluronic acid enriched media.
Zhang, M., Black, G., McDonald, F., Sturrock, S., Humphery-Smith, I. & Charnock, S., Apr 2007, In: Proteomics. 7, 9, p. 1379-1390Research output: Contribution to journal › Article › peer-review
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2006
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a β-N-acetylglucosaminidase and not a hyaluronidase
Sheldon, W., Macauley, M., Taylor, E., Robinson, C., Charnock, S., Davies, G., Vocadlo, D. & Black, G., Oct 2006, In: Biochemical Journal. 399, 2, p. 241-247Research output: Contribution to journal › Article › peer-review
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Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
Dennis, R., Black, G., Macauley, M., Taylor, E., Stubbs, K., Davies, G., Turkenburg, J., Hart, S. J. & Vocadlo, D., Mar 2006, In: Nature structural & molecular biology. 13, p. 365-371Research output: Contribution to journal › Article › peer-review
Open Access -
2005
Characterisation of the nitrile hydratase gene clusters of Rhodococcus erythropolis strains AJ270 and AJ300 and Microbacterium sp. AJ115 indicates horizontal gene transfer and reveals an insertion of IS1166
O'Mahony, R., Doran, J., Coffey, L., Cahill, O., Black, G. & O'Reilly, C., Apr 2005, In: Antonie van Leeuwenhoek. 87, 3, p. 221-232Research output: Contribution to journal › Article › peer-review
Open Access -
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded β-helix
Smith, N. L., Taylor, E. J., Black, A., Charnock, S. J., Turkenburg, J. P., Dodson, E. J., Davies, G. J. & Black, G., 6 Dec 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 49, p. 17652-17657 5 p.Research output: Contribution to journal › Article › peer-review
Open Access