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Research interests
Dr McKay is an Associate Professor in the Department of Applied Sciences, with an expertise in molecular epidemiology specifically focused on the developmental origins of health and disease. After completing her first degree in Medical Microbiology at Newcastle University, Jill joined the Human Nutrition Research Centre at Newcastle to undertake a PhD in Molecular Nutrition under the supervision of Prof. John Mathers. Jill continued her career at Newcastle University as a post-doctoral researcher and subsequently Lecturer in Molecular Epidemiology before joining Northumbria University as Senior Lecturer in 2018, and subsequently promoting to Associate Professor in 2020.
In her >20 year career, Jill’s research interests have focused towards understanding the molecular mechanisms underpinning the relationship between early life exposures and subsequent later life health outcomes. During her early career, she utilised animal models and human cohorts to investigate the associations between maternal folate intake during pregnancy and offspring health, using a range of molecular techniques including gene expression analysis (candidate specific and transcriptomic approaches), epigenetic analysis (DNA methylation assessment at the candidate and methylomic level) and genotyping.
In her academic role, Jill’s portfolio has expanded to include interests in a range of exposures which may influence health outcomes including childhood cancer, the late health effects of childhood cancer survivors, obesity and neurocognition. In particular, she has developed a unique, cutting-edge internationally recognized research portfolio investigating the influence of early life exposures on childhood leukaemia, with a focus on understanding how exposures may influence molecular events initiating disease. Her ongoing project supported by the World Cancer Research Fund is currently investigating how maternal folate levels may influence the molecular triggers (including chromosomal translocations and DNA methylation changes) involved in the initiation of childhood leukaemia development (The role of maternal folate in childhood leukaemia development - WCRF International). Meanwhile, she is also investigating the potential role exposure to microbial diversity through day care attendance may play in the development of non-communicable diseases (including leukaemia) in children.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
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The role of maternal folate in childhood leukemia initiation; understanding the molecular mechanisms
McKay, J., Padget, K., Schwalbe, E., Todryk, S. & Pal, D.
World Cancer Research Fund International
1/04/23 → 31/03/27
Project: Research
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Environmental microbiome in the home and daycare settings during the COVID-19 pandemic, and potential risk of non-communicable disease in children
McKay, J., Crown, M., Bashton, M., Pearce, D., Entwistle, J. & Sangal, V., Feb 2024, In: Environmental Microbiology Reports. 16, 1, 11 p., e13233.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth
Ghantous, A., Gonseth Nussle, S., Nassar, F. J., Spitz, N., Novoloaca, A., Krali, O., Nickels, E., Cahais, V., Cuenin, C., Roy, R., Li, S., Caron, M., Lam, D., Fransquet, P. D., Casement, J., Strathdee, G., Pearce, M. S., Hansen, H. M., Lee, H-H., Lee, Y. S., & 11 others , 23 Oct 2024, In: Molecular Cancer. 23, 1, 8 p., 238.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Influence of maternal folate depletion on Art3 DNA methylation in the murine adult brain: potential consequences for brain and neurocognitive health
Kok, D. E., Saunders, R., Nelson, A., Smith, D., Ford, D., Mathers, J. C. & McKay, J. A., 1 May 2024, In: Mutagenesis. 39, 3, p. 196-204 9 p., geae007.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Downloads (Pure) -
Intake and biomarkers of folate and folic acid as determinants of chemotherapy-induced toxicities in patients with colorectal cancer: a cohort study
Kok, D. E., van Duijnhoven, F. J. B., Lubbermanb, F. J. E., McKay, J. A., van Lanen, A-S., Winkels, R. M., Wesselink, E., van Halterend, H. K., de Wilt, J. H. W., Ulrich, C. M., Ulvik, A., Ueland, P. M. & Kampman, E., 1 Feb 2024, In: The American Journal of Clinical Nutrition. 119, 2, p. 294-301 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)44 Downloads (Pure) -
Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review
Zwart, N. R. K., Franken, M. D., Tissing, W. J. E., Lubberman, F. J. E., McKay, J., Kampman, E. & Kok, D. E., 1 Aug 2023, In: Critical reviews in oncology/hematology. 188, 104061.Research output: Contribution to journal › Literature review › peer-review
Open AccessFile2 Citations (Scopus)147 Downloads (Pure)