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Personal profile

Research interests

My research focus is on neuronal aging, with an emphasis on understanding the molecular mechanisms underpinning observed decreases in DNA Topoisomerase II beta (TOP2B) with aging. This includes investigating the epigenetic mechanisms underpinning decreased expression and the impact on DNA repair and transcription as a result. In collaboration, I am also involved in investigating the mechanisms of the developmental origins of translocations seen in childhood leukaemia and therapy-related translocations. 

Biography

Upon completion of a BSc (Hons) in Biomedical Science at Sunderland University, Dr Padget gained her PhD in Biochemistry at Newcastle University in 1998 in which she developed quantitative methodologies to determine levels of DNA Topoisomerase II (Topo II) in Acute Lymphoblastic Leukaemia patients to understand their therapeutic responses and evaluate the potential of personalised therapy. Dr Padget continued her research on the biochemistry of Topo II and its role as a therapeutic target and in DNA repair at Newcastle University until 2007 when she joined Northumbria University.

Dr Padget current research reflects her interest in ageing mechanisms, centred around Topo II and also childhood Leukaemia.  In addition, she teaches on a range of Biomedical Science undergraduate modules as well as the first year of the four-year Doctor of Medicine (MD) programme ran in partnership with St. George’s University of Grenada School of Medicine (SGU). She is a Senior Fellow of the Higher Education Academy (SFHEA) in recognition of her teaching practice and support for students and staff and mentors’ new staff in gaining professional recognition as well as assessing applications. Dr Padget is also an External Examiner at Salford University and is a member of the Applied Sciences Athena Swan Committee.

Dr Padget is currently Deputy Head of the Applied Sciences Department at Northumbria and provides support to ensure the effective and efficient running of the Department in line with University Strategy and Vision.

Education/Academic qualification

Teaching & Learning, PCAPL

11 Oct 200731 Dec 2099

Award Date: 11 Oct 2007

Biochemistry, PhD

1 Sep 199431 Dec 2099

Award Date: 1 Sep 1994

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