Search results

• 2023

  Engineering Approaches for Cellular Therapeutics and Diagnostics

  Torun, H., Agrawal, P., Markwell, C., Fu, Y., Todryk, S. & Moschos, S., 6 Apr 2023, Emerging Drug Delivery and Biomedical Engineering Technologies : Transforming Therapy. Lamprou, D. (ed.). 1st ed. Boca Raton, US: Routledge, p. 157-169 13 p. (Drugs and the Pharmaceutical Sciences).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2022

  A multinational Delphi consensus to end the COVID-19 public health threat

  Lazarus, J. V., Romero, D., Kopka, C. J., Karim, S. A., Abu-Raddad, L. J., Almeida, G., Baptista-Leite, R., Barocas, J. A., Barreto, M. L., Bar-Yam, Y., Bassat, Q., Batista, C., Bazilian, M., Chiou, S-T., Del Rio, C., Dore, G. J., Gao, G. F., Gostin, L. O., Hellard, M., Jimenez, J. L., & 22 othersKang, G., Lee, N., Matičič, M., McKee, M., Nsanzimana, S., Oliu-Barton, M., Pradelski, B., Pyzik, O., Rabin, K., Raina, S., Rashid, S. F., Rathe, M., Saenz, R., Singh, S., Trock-Hempler, M., Villapol, S., Yap, P., Binagwaho, A., Kamarulzaman, A., El-Mohandes, A., COVID-19 Consensus Statement Panel & Moschos, S. A., 10 Nov 2022, In: Nature. 611, 7935, p. 332-345 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Public Health 100%
  • Threat 75%
  • COVID-19 75%
  • Health 50%
  • Interpersonal Communication 50%
  55 Citations (Scopus)

  1 Downloads (Pure)

• Bacterial Adaptation to Venom in Snakes and Arachnida

  Esmaeilishirazifard, E., Usher, L., Trim, C., Denise, H., Sangal, V., Tyson, G. H., Barlow, A., Redway, K. F., Taylor, J. D., Kremyda-Vlachou, M., Davies, S., Loftus, T. D., Lock, M. M. G., Wright, K., Dalby, A., Snyder, L. A. S., Wuster, W., Trim, S. & Moschos, S. A., 29 Jun 2022, In: Microbiology spectrum. 10, 3, p. 1-16 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Venom 100%
  • Bite Wound 28%
  • Naja 28%
  • Tarantula 14%
  • Arachnid 14%
  9 Citations (Scopus)

  30 Downloads (Pure)

• Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics

  O'Sullivan, J., Muñoz-Muñoz, J., Turnbull, G., Sim, N., Penny, S. & Moschos, S., 14 Jul 2022, In: RSC Advances. 12, 32, p. 20432-20446 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Givosiran 100%
  • Asialoglycoprotein Receptor 50%
  • Nusinersen 50%
  • Patisiran 50%
  • Galactosamine 50%
  5 Citations (Scopus)

  12 Downloads (Pure)

• The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)

  Neatu, R., Enekwa, I., Thompson, D., Schwalbe, E., Fois, G., Abdelaal, G., Veuger, S., Frick, M., Braubach, P. & Moschos, S., 8 Dec 2022, In: Non-coding RNA. 8, 6, 13 p., 83.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • MUC5B 100%
  • Long Non-Coding RNA 33%
  8 Downloads (Pure)

• The Idiopathic Pulmonary Fibrosis-Associated SNP rs35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)

  Enekwa, I., Neatu, R., Fois, G., Frick, M. & Moschos, S., 1 May 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, C109, p. A4974-A4974

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access
• 2020

  A new threat from an old enemy: Re-emergence of coronavirus (Review)

  Docea, A. O., Tsatsakis, A., Albulescu, D., Cristea, O., Zlatian, O., Vinceti, M., Moschos, S. A., Tsoukalas, D., Goumenou, M., Drakoulis, N., Dumanov1, J. M., Tutelyan, V. A., Onischenko, G. G., Aschner, M., Spandidos, D. A. & Calina, D., Jun 2020, In: International Journal of Molecular Medicine. 45, 6, p. 1631-1643 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Exercise 100%
  • Diseases 100%
  • Threat 100%
  • Researcher 50%
  • Epidemic 50%
  127 Citations (Scopus)

  10 Downloads (Pure)

• Bioengineering bacterial outer membrane vesicles as delivery system for RNA therapeutics targeted to lung epithelial cytosols

  Eftychiou, E., Brown, N., Cheung, W., Fois, G., Frick, M. & Moschos, S., 12 May 2020, p. 1089.

  Research output: Contribution to conference › Poster

  Open Access

  File

  • Membrane Vesicle 100%
  • Protein 50%
  • Surface Property 50%
  • Outer Membrane 50%
  • Transmission Electron Microscopy 50%
  69 Downloads (Pure)

• Comprehensive Analysis of Drugs to Treat SARS‑CoV‑2 Infection: Mechanistic Insights Into Current COVID‑19 Therapies (Review)

  Nitulescu, G., Paunescu, H., Moschos, S., Petrakis, D., Nitulescu, G., Ion, G., Spandidos, D. A., Nikolouzakis, T., Drakoulis, N. & Tsatsakis, A., Aug 2020, In: International Journal of Molecular Medicine. 46, 2, p. 467-488 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Therapeutic Procedure 100%
  • COVID-19 75%
  • Combination Therapy 50%
  • Severe Acute Respiratory Syndrome Coronavirus 2 50%
  • Analysis 25%
  102 Citations (Scopus)

  25 Downloads (Pure)
• 2019

  Measuring the action of oligonucleotide therapeutics in the lung at the cell type specific level by Tissue Disruption and Cell Sorting (TDCS): In vivo cell type-specific oligonucleotide PK/PD

  Graves, H., Evans, S., Fauler, M., Frick, M. & Moschos, S., 2019, Oligonucleotide-based Therapies. Gissberg, O., Zain, R. & Lundin, K. (eds.). New York, NY: Springer, p. 187-203 (Methods in Molecular Biology; no. 2036).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  Open Access

  File

  • Drug 100%
  • Oligonucleotide 66%
  • Antibody 66%
  • Cell Culture 66%
  • RNA 33%
  24 Downloads (Pure)

• Predicting oligonucleotide therapeutic efficacy at the population level

  Theotokis, P. I., Usher, L., Kortschak, C. K., Schwalbe, E. & Moschos, S., 1 Nov 2019, In: Hellenic Journal of Nuclear Medicine. 22, Supplement 2, p. 182 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Single-Nucleotide Polymorphism 100%
  • Oligonucleotide 75%
  • DNA 25%
  • Sampling 25%
  • Mediator 25%

• RACE-SEQ and Population-Wide Polymorphism Susceptibility Testing for Endonucleolytically Active, RNA-Targeting Therapeutics

  Usher, L., Theotokis, P. I. & Moschos, S. A., 1 Jan 2019, Methods in Molecular Biology. Humana Press, p. 283-305 23 p. (Methods in Molecular Biology; vol. 2036).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • RNA 100%
  • Replicon 33%
  • Ligase 33%
  • Rapid Amplification of cDNA Ends 33%
  • High Throughput Sequencing 33%

• RACE-SEQ and population-wide polymorphism susceptibility testing for endonucleotically active, RNA-targeting therapeutics: RACE-SEQing RNA cleaving drug mechanism of action

  Usher, L., Theotokis, P. & Moschos, S., 2019, Oligonucleotide-based Therapies. Gissberg, O., Zain, R. & Lundin, K. (eds.). New York, NY: Springer, p. 283-305 (Methods in Molecular Biology; no. 2036).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  Open Access

  File

  • Drug Mechanism 100%
  20 Downloads (Pure)

• The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and Parasites (iVAMP)

  Ul-Hasan, S., Rodriguez-Roman, E., Reitzel, A., Adams, R., Herzig, V., Trim, S., Saviola, A., Nobile, C., Stiers, E., Moschos, S., Keiser, C., Petras, D., Moran, Y. & Colston, T., 1 Oct 2019, In: Toxicon: X. 4, 100016.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microorganism 100%
  • Parasite 66%
  • Microbiome 33%
  • Host 33%
  • Bacterium 16%
  16 Citations (Scopus)

  106 Downloads (Pure)
• 2018

  A novel antifungal property for the Bacillus licheniformis ComX pheromone and its possible role in inter-kingdom cross-talk

  Esmaeilishirazifard, E., Dariush, A., Moschos, S. A. & Keshavarz, T., Jun 2018, In: Applied Microbiology and Biotechnology. 102, 12, p. 5197-5208

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quorum Sensing 100%
  • Pheromone 75%
  • Bacillus Licheniformis 50%
  • Bacillus 50%
  • Fungus Growth 25%
  10 Citations (Scopus)

  16 Downloads (Pure)

• Extracellular vesicles and their nucleic acids for biomarker discovery

  Momen-Heravi, F., Getting, S. J. & Moschos, S., 3 Aug 2018, (E-pub ahead of print) In: Pharmacology and Therapeutics. 192, p. 170-187

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Bioassay 100%
  74 Citations (Scopus)

  39 Downloads (Pure)

• Gene therapies are proving their worth, but with million dollar price tags, it’s not clear who should pay for them

  Moschos, S., 26 Mar 2018, The Conversation.

  Research output: Contribution to specialist publication › Article

  Open Access

• PulmoScreen: A Novel Exhaled Breath Condensate Device

  Clements, C., Wilkinson, A., Shah, K. & Moschos, S., 22 Nov 2018.

  Research output: Contribution to conference › Poster

  Open Access

  File

  • Breathing 100%
  • Protein 40%
  • Biomolecules 40%
  • Health 20%
  • DNA 20%
  82 Downloads (Pure)

• PulmoScreen: Solving exhaled breath molecular diagnostics

  Moschos, S., Nov 2018.

  Research output: Contribution to conference › Other
• 2017

  Bedside NGS diagnostics for the oligonucleotide therapeutics market: from patient selection to drug efficacy quantification

  Moschos, S., 12 Jul 2017.

  Research output: Contribution to conference › Other › peer-review

• BreatheIN: Realising the Clinical Potential of Oligonucleotide Rx for Respiratory Disease

  Moschos, S., 1 Feb 2017.

  Research output: Contribution to conference › Other › peer-review

• BreatheIN: Realising the Clinical Potential of Oligonucleotide Rx for Respiratory Disease

  Moschos, S., Feb 2017.

  Research output: Contribution to conference › Other

• Exhaled breath condensate collection device and a kit of parts thereof

  Moschos, S. & Kale, I., 13 Sep 2017

  Research output: Patent

  • Outlet Port 100%
  • Condensate 74%
  • Exhaled Breath Condensate Collection Device 50%
  • Inlet Port 25%
  • Lid 25%

• Field-deployable, Quantitative, Rapid Identification of Active Ebola Virus Infection in Unprocessed Blood

  Shah, K., Bentley, E., Tyler, A., Richards, K., Wright, E., Easterbrook, L., Lee, D., Cleaver, C., Usher, L., Burton, J., Pitman, J., Bruce, C., Norwood, D. & Moschos, S., 1 Nov 2017, In: Chemical Science. 8, 11, p. 2041-6539

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Filovirus 100%
  • Freeze Thawing 50%
  • Mass Screening 50%
  • Lentivirus 50%
  • Virus Genome 50%
  8 Citations (Scopus)

  92 Downloads (Pure)

• Genomic and molecular characterization of a novel quorum sensing molecule in Bacillus licheniformis

  Esmaeilishirazifard, E., De Vizio, D., Moschos, S. & Keshavarz, T., 8 Apr 2017, In: AMB Express. 7, 78

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quorum Sensing 100%
  • Primary Structure 60%
  • Molecule 60%
  • Pheromone 60%
  • Peptide 40%
  12 Citations (Scopus)

  4 Downloads (Pure)

• Oligonucleotide therapies for the lung: ready to return to the clinic?

  Kumar, M. & Moschos, S., 22 Nov 2017, (E-pub ahead of print) In: Molecular Therapy. 25, 12, p. 2604-2606

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Liposome 100%
  • Transcytosis 100%
  • Cytosol 100%
  • Oligonucleotide Therapy 100%
  • Cell Penetrating Peptide 100%
  9 Citations (Scopus)

  3 Downloads (Pure)

• Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs

  Theotokis, P., Usher, L., Kortschak, C. K., Schwalbe, E. & Moschos, S., 15 Sep 2017, (E-pub ahead of print) In: Molecular Therapy - Nucleic Acids. 9, p. 22-33

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Argonaute 2 Protein 100%
  • Potentiation 33%
  • Quasispecies 33%
  • Replicon 33%
  • Pharmacogenomics 33%
  2 Citations (Scopus)

  14 Downloads (Pure)

• RNA therapeutics for lung disease.

  Moschos, S., 1 Mar 2017.

  Research output: Contribution to conference › Other
• 2016

  Clinical potential of oligonucleotide-based therapeutics in the respiratory system

  Moschos, S., Usher, L. & Lindsay, M., 19 Oct 2016, (E-pub ahead of print) In: Pharmacology & Therapeutics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clinical Trial 100%
  • Combination Therapy 100%
  • Oligonucleotide 100%
  • Oligonucleotide Delivery 100%
  • Nucleic Acid 100%
  23 Citations (Scopus)

  23 Downloads (Pure)

• Direct Bedside Quantification of DNA and RNA in Crude, Whole Biofluids

  Shah, K., Bentley, E., Usher, L., Ozuna, A., Tyler, A., Richards, K., Edge, D., Right, E., Lee, M., Nazareth, N., Norwood, D. & Moschos, S., Sep 2016.

  Research output: Contribution to conference › Poster

• Ebolacheck: Delivering Molecular Diagnostics at the Point of Need

  Moschos, S., Feb 2016.

  Research output: Contribution to conference › Other

• EbolaCheck: Point of Care qPCR matches lab-based clinical diagnostic laboratory Ebolavirus detection sensitivity

  Moschos, S., May 2016.

  Research output: Contribution to conference › Other

• EbolaCheck: Realising Point of Care Molecular Diagnostics at the Point of Need

  Shah, K., Richards, K., Bruce, C., Vipond, R., Easterbrook, L., Opoku-Okrah, C., Debrah, A-Y., Wright, E., Carrol, M., Norwood, D. & Moschos, S., May 2016.

  Research output: Contribution to conference › Poster

• Making a Difference: Leveraging Innovation to Meet Clinical Need

  Moschos, S. & Maltezou, H., Nov 2016.

  Research output: Contribution to conference › Other

  • Laboratory 100%
  • RNA 66%
  • Assay 66%
  • Medicine 33%
  • Gene Therapy 33%

• Molecular Diagnostics at the Point of Care: Ebola and Beyond

  Moschos, S., Mar 2016.

  Research output: Contribution to conference › Other

• RACE-seq(ing) Argonaute-2 cleavage precision

  Usher, L. & Moschos, S., Sep 2016.

  Research output: Contribution to conference › Poster

• Resolving Molecular Diagnostics Need for Ebola, Advancing Point of Care Testing for the West

  Moschos, S., Apr 2016.

  Research output: Contribution to conference › Other

• SEQing Drug Activity – from the Bench to the Bedside

  Moschos, S., Nov 2016.

  Research output: Contribution to conference › Other

• Transitioning a gene therapy mechanism of action confirmation assay from the bench to the bedside

  Usher, L., Kortschak, C. K. & Moschos, S., 15 Apr 2016, In: Human Gene Therapy. 27, 7, p. A13-A14

  Research output: Contribution to journal › Article
• 2015

  A common brain microbiome in normal rodents & humans: evidence on entry routes with an intact blood-brain-barrier

  Fraszczak, M., Usher, L., Frick, M., Lennerz, J. & Moschos, S., Jun 2015.

  Research output: Contribution to conference › Poster

• CL2/4 Validation Strategy for EbolaCheck, a whole blood POC NAT MDx system

  Moschos, S., Mar 2015.

  Research output: Contribution to conference › Other

• Ebola Check: Delivering molecular diagnostics at the point of need

  Moschos, S., 12 Dec 2015, (E-pub ahead of print).

  Research output: Contribution to conference › Paper › peer-review

  • Reverse Transcription Polymerase Chain Reaction 100%
  • Ebola Virus 50%
  • Laboratory Test 50%
  • Volume 50%
  • Molecular Diagnostics 50%

• EbolaCheck: Realising point of care molecular diagnostics

  Shah, K. & Moschos, S., May 2015.

  Research output: Contribution to conference › Poster

• EbolaCheck - the first true POC qRT-PCR device for 3rd world humanitarian crisis responses

  Moschos, S., Jun 2015.

  Research output: Contribution to conference › Other

• From Molecular Biomarkers to Point of Care Molecular Diagnostics: Lessons from Ebola, Opportunities Beyond

  Moschos, S., Oct 2015.

  Research output: Contribution to conference › Other

• Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis

  Moschos, S., 31 Aug 2015, In: Expert Review of Molecular Diagnostics. 15, 10, p. 1237-40

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Molecular Diagnosis 100%
  • Hemorrhagic Fever 100%
  • Health Care Quality 100%
  • Differential Diagnosis 100%
  • Nucleic Acid 100%
  3 Citations (Scopus)

• Low complexity all-pass based polyphase decimation filters for ECG monitoring

  Eminaga, Y., Coskun, A., Moschos, S. & Kale, I., 2015.

  Research output: Contribution to conference › Poster

  • Acquisition System 100%
  • Delta Modulator 100%
  7 Citations (Scopus)

• Molecular Diagnostics & Next Gen Sequencing: Choosing the right tools for the right task

  Moschos, S., Nov 2015.

  Research output: Contribution to conference › Other

• Molecular diagnostics at the bedside, electricity or not: From Ebola to NGS

  Moschos, S., Jul 2015.

  Research output: Contribution to conference › Other

• Overcoming the challenges of biomarker adoption in clinical trials for rare disease treatment

  Moschos, S., Jun 2015.

  Research output: Contribution to conference › Other