α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters

Avin Ramanjooloo; Thierry Cresteil; Cindy Lebrasse; Girish Beedessee; Preeti Oogarah; Rob W.M. Van Soest; Daniel E.P. Marie

doi:10.1080/14786419.2014.945173

α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters

Avin Ramanjooloo, Thierry Cresteil, Cindy Lebrasse, Girish Beedessee, Preeti Oogarah, Rob W.M. Van Soest, Daniel E.P. Marie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC₅₀ value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Natural Product Research
Volume	29
Issue number	4
DOIs	https://doi.org/10.1080/14786419.2014.945173
Publication status	Published - 16 Feb 2015
Externally published	Yes

Keywords

marine sponges
Mauritius
postprandial hyperglycemia
α-glucosidase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2014.945173

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title = "α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters",

abstract = "This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC50 value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.",

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author = "Avin Ramanjooloo and Thierry Cresteil and Cindy Lebrasse and Girish Beedessee and Preeti Oogarah and {Van Soest}, {Rob W.M.} and Marie, {Daniel E.P.}",

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doi = "10.1080/14786419.2014.945173",

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T1 - α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters

AU - Ramanjooloo, Avin

AU - Cresteil, Thierry

AU - Lebrasse, Cindy

AU - Beedessee, Girish

AU - Oogarah, Preeti

AU - Van Soest, Rob W.M.

AU - Marie, Daniel E.P.

PY - 2015/2/16

Y1 - 2015/2/16

N2 - This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC50 value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.

AB - This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC50 value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.

KW - marine sponges

KW - Mauritius

KW - postprandial hyperglycemia

KW - α-glucosidase

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SN - 1478-6419

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ER -

α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters

Abstract

Keywords

UN SDGs

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