2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms

Marie Cellier, Amandine Gignoux, Arthur James, Sylvain Orenga, John Perry, Shaun Robinson, Stephen Stanforth, Graeme Turnbull

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
8 Downloads (Pure)

Abstract

A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.
Original languageEnglish
Pages (from-to)5694-5698
JournalBioorganic & Medicinal Chemistry Letters
Volume25
Issue number24
DOIs
Publication statusPublished - 15 Dec 2015

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