A Cellular Automaton Model of the Effects of Maspin on Cell Migration

Mohammad Al-Mamun; Alamgir Hossain; Muhammad Alam; Rosemary Bass

doi:10.1007/978-3-319-00578-2_8

A Cellular Automaton Model of the Effects of Maspin on Cell Migration

Mohammad Al-Mamun, Alamgir Hossain, Muhammad Alam, Rosemary Bass

Northumbria University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy. © Springer International Publishing Switzerland 2013.

Original language	English
Title of host publication	7th International Conference on Practical Applications of Computational Biology & Bioinformatics
Place of Publication	London
Publisher	Springer
Pages	53-60
Volume	222
ISBN (Print)	978-3-319-00577-5
DOIs	https://doi.org/10.1007/978-3-319-00578-2_8
Publication status	Published - 2013

Keywords

Cell migration
Maspin
mathematical model
neural network
Serpin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-00578-2_8

Cite this

@inbook{1e34ffd467824833b8bf0a7fd3de9548,

title = "A Cellular Automaton Model of the Effects of Maspin on Cell Migration",

abstract = "Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy. {\textcopyright} Springer International Publishing Switzerland 2013.",

keywords = "Cell migration, Maspin, mathematical model, neural network, Serpin",

author = "Mohammad Al-Mamun and Alamgir Hossain and Muhammad Alam and Rosemary Bass",

year = "2013",

doi = "10.1007/978-3-319-00578-2_8",

language = "English",

isbn = "978-3-319-00577-5",

volume = "222",

pages = "53--60",

booktitle = "7th International Conference on Practical Applications of Computational Biology & Bioinformatics",

publisher = "Springer",

address = "Germany",

}

TY - CHAP

T1 - A Cellular Automaton Model of the Effects of Maspin on Cell Migration

AU - Al-Mamun, Mohammad

AU - Hossain, Alamgir

AU - Alam, Muhammad

AU - Bass, Rosemary

PY - 2013

Y1 - 2013

N2 - Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy. © Springer International Publishing Switzerland 2013.

AB - Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy. © Springer International Publishing Switzerland 2013.

KW - Cell migration

KW - Maspin

KW - mathematical model

KW - neural network

KW - Serpin

U2 - 10.1007/978-3-319-00578-2_8

DO - 10.1007/978-3-319-00578-2_8

M3 - Chapter

SN - 978-3-319-00577-5

VL - 222

SP - 53

EP - 60

BT - 7th International Conference on Practical Applications of Computational Biology & Bioinformatics

PB - Springer

CY - London

ER -

A Cellular Automaton Model of the Effects of Maspin on Cell Migration

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this