A comparison between solid phase extraction and supercritical fluid extraction for the determination of fluconazole from animal feed

Sharmin Khundker; John Dean; Peter Jones

doi:10.1016/0731-7085(95)01582-5

A comparison between solid phase extraction and supercritical fluid extraction for the determination of fluconazole from animal feed

Sharmin Khundker, John Dean, Peter Jones

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The application of supercritical fluid extraction with carbon dioxide and modified carbon dioxide for the determination of fluconazole from an animal feed was studied. A fractional factorial design approach was used to examine the significant experimental variables for quantitative extraction of fluconazole. Gas chromatography with either flame ionisation or mass selective detection was used for quantitation of the extracts. The results indicated that modifier (methanol) had the greatest effect on the recovery of fluconazole from the animal feed.

Original language	English
Pages (from-to)	1441-1447
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	13
Issue number	12
DOIs	https://doi.org/10.1016/0731-7085(95)01582-5
Publication status	Published - Nov 1995

Keywords

animal feed
fluconazole
fractional factorial design
gas chromatography
supercritical fluid extraction

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10.1016/0731-7085(95)01582-5

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abstract = "The application of supercritical fluid extraction with carbon dioxide and modified carbon dioxide for the determination of fluconazole from an animal feed was studied. A fractional factorial design approach was used to examine the significant experimental variables for quantitative extraction of fluconazole. Gas chromatography with either flame ionisation or mass selective detection was used for quantitation of the extracts. The results indicated that modifier (methanol) had the greatest effect on the recovery of fluconazole from the animal feed.",

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AB - The application of supercritical fluid extraction with carbon dioxide and modified carbon dioxide for the determination of fluconazole from an animal feed was studied. A fractional factorial design approach was used to examine the significant experimental variables for quantitative extraction of fluconazole. Gas chromatography with either flame ionisation or mass selective detection was used for quantitation of the extracts. The results indicated that modifier (methanol) had the greatest effect on the recovery of fluconazole from the animal feed.

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KW - fluconazole

KW - fractional factorial design

KW - gas chromatography

KW - supercritical fluid extraction

UR - https://www.scopus.com/pages/publications/0029597393

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DO - 10.1016/0731-7085(95)01582-5

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ER -

A comparison between solid phase extraction and supercritical fluid extraction for the determination of fluconazole from animal feed

Abstract

Keywords

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