A comprehensive review on tyrosinase inhibitors

Samaneh Zolghadri; Asieh Bahrami; Mahmud Tareq Hassan Khan; J. Munoz-munoz; F. Garcia-molina; F. Garcia-canovas; Ali Akbar Saboury

doi:10.1080/14756366.2018.1545767

A comprehensive review on tyrosinase inhibitors

Samaneh Zolghadri, Asieh Bahrami, Mahmud Tareq Hassan Khan, J. Munoz-munoz, F. Garcia-molina, F. Garcia-canovas, Ali Akbar Saboury

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946 Citations (Scopus)

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Abstract

Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

Original language	English
Pages (from-to)	279-309
Number of pages	31
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	34
Issue number	1
Early online date	3 Jan 2019
DOIs	https://doi.org/10.1080/14756366.2018.1545767
Publication status	E-pub ahead of print - 3 Jan 2019

Keywords

Tyrosinase
Inhibitor
Depigmentation agents
Antibrowning compounds

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A comprehensive review on tyrosinase inhibitorsFinal published version, 3.68 MBLicence: CC BY

Cite this

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AU - Zolghadri, Samaneh

AU - Bahrami, Asieh

AU - Hassan Khan, Mahmud Tareq

AU - Munoz-munoz, J.

AU - Garcia-molina, F.

AU - Garcia-canovas, F.

AU - Saboury, Ali Akbar

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AB - Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

KW - Tyrosinase

KW - Inhibitor

KW - Depigmentation agents

KW - Antibrowning compounds

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A comprehensive review on tyrosinase inhibitors

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