A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Kate Lauder, Domiziana Masci, Anita Toscani, Aya Al Mekdad, Gary Black, Nicola Brown, Nicholas J. Turner, Renzo Luisi, Daniele Castagnolo*

*Corresponding author for this work

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Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.

Original languageEnglish
Pages (from-to)8982-8986
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number40
Early online date25 Sep 2019
DOIs
Publication statusPublished - 28 Oct 2019

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