A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A

Alan Ironmonger, Mark Shipton, Fiona Slater, Pete Szeto, Matthew Unthank, Francois-Rene Alexandre, Catherine Caillet, Cyril Dousson

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
10 Downloads (Pure)

Abstract

A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxiliary. The practicality of this transformation is demonstrated on a multi-gram scale.
Original languageEnglish
Pages (from-to)2154-2156
Number of pages3
JournalTetrahedron Letters
Volume59
Issue number22
Early online date11 Apr 2018
DOIs
Publication statusPublished - 30 May 2018

Fingerprint Dive into the research topics of 'A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus on-route to a key intermediate in the synthesis of GSK2248761A'. Together they form a unique fingerprint.

Cite this