A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing.

Vartul Sangal, Andreas Burkovski, Alison Hunt, Becky Edwards, Jochen Blom, Paul Hoskisson

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.
Original languageEnglish
Pages (from-to)54-57
JournalInfection, Genetics and Evolution
Volume21
DOIs
Publication statusPublished - 4 Jan 2014

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