A link between transcription fidelity and pausing in vivo

Pamela Gamba, Katherine James, Nikolay Zenkin

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
4 Downloads (Pure)

Abstract

Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.
Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalTranscription
Volume8
Issue number2
Early online date24 Jan 2017
DOIs
Publication statusPublished - 15 Mar 2017
Externally publishedYes

Fingerprint

Dive into the research topics of 'A link between transcription fidelity and pausing in vivo'. Together they form a unique fingerprint.

Cite this