A link between transcription fidelity and pausing in vivo

Pamela Gamba; Katherine James; Nikolay Zenkin

doi:10.1080/21541264.2016.1274812

A link between transcription fidelity and pausing in vivo

Pamela Gamba, Katherine James, Nikolay Zenkin

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Abstract

Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

Original language	English
Pages (from-to)	99-105
Number of pages	7
Journal	Transcription
Volume	8
Issue number	2
Early online date	24 Jan 2017
DOIs	https://doi.org/10.1080/21541264.2016.1274812
Publication status	Published - 15 Mar 2017
Externally published	Yes

Keywords

collisions of transcription with replication
fidelity
Gre
misincorporation
pausing
proofreading
TFIIS
transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21541264.2016.1274812Licence: CC BY

A link between transcription fidelity and pausing in vivoFinal published version, 503 KBLicence: CC BY

Cite this

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abstract = "Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.",

keywords = "collisions of transcription with replication, fidelity, Gre, misincorporation, pausing, proofreading, TFIIS, transcription",

author = "Pamela Gamba and Katherine James and Nikolay Zenkin",

note = "This work was supported by grants from the UK Biotechnology and Biological Sciences Research Council (BB/L010003/1), Wellcome Trust (102851) and Leverhulme Trust (PLP-2014-229), awarded to N.Z.",

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AU - Gamba, Pamela

AU - James, Katherine

AU - Zenkin, Nikolay

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PY - 2017/3/15

Y1 - 2017/3/15

N2 - Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

AB - Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

KW - collisions of transcription with replication

KW - fidelity

KW - Gre

KW - misincorporation

KW - pausing

KW - proofreading

KW - TFIIS

KW - transcription

U2 - 10.1080/21541264.2016.1274812

DO - 10.1080/21541264.2016.1274812

M3 - Article

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VL - 8

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EP - 105

JO - Transcription

JF - Transcription

IS - 2

ER -

A link between transcription fidelity and pausing in vivo

Abstract

Keywords

UN SDGs

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