A link between transcription fidelity and pausing in vivo

Pamela Gamba; Katherine James; Nikolay Zenkin

doi:10.1080/21541264.2016.1274812

A link between transcription fidelity and pausing in vivo

Pamela Gamba, Katherine James, Nikolay Zenkin

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Abstract

Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

Original language	English
Pages (from-to)	99-105
Number of pages	7
Journal	Transcription
Volume	8
Issue number	2
Early online date	24 Jan 2017
DOIs	https://doi.org/10.1080/21541264.2016.1274812
Publication status	Published - 15 Mar 2017
Externally published	Yes

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10.1080/21541264.2016.1274812Licence: CC BY

A link between transcription fidelity and pausing in vivoFinal published version, 503 KBLicence: CC BY

Cite this

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abstract = "Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.",

keywords = "collisions of transcription with replication, fidelity, Gre, misincorporation, pausing, proofreading, TFIIS, transcription",

author = "Pamela Gamba and Katherine James and Nikolay Zenkin",

note = "This work was supported by grants from the UK Biotechnology and Biological Sciences Research Council (BB/L010003/1), Wellcome Trust (102851) and Leverhulme Trust (PLP-2014-229), awarded to N.Z.",

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AU - James, Katherine

AU - Zenkin, Nikolay

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N2 - Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

AB - Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.

KW - collisions of transcription with replication

KW - fidelity

KW - Gre

KW - misincorporation

KW - pausing

KW - proofreading

KW - TFIIS

KW - transcription

U2 - 10.1080/21541264.2016.1274812

DO - 10.1080/21541264.2016.1274812

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JO - Transcription

JF - Transcription

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A link between transcription fidelity and pausing in vivo

Abstract

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