A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

Paolo Vincetti; Anna Brianza; Nicolò Scalacci; Gabriele Costantino; Daniele Castagnolo; Marco Radi

doi:10.1016/j.tetlet.2016.02.068

A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

Paolo Vincetti, Anna Brianza, Nicolò Scalacci, Gabriele Costantino, Daniele Castagnolo, Marco Radi

Northumbria University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A fast, versatile and practical microwave-assisted multicomponent protocol for the synthesis of substituted benzofuran-2-carboxamides has been developed. The present method proved to be effective on a series of commercially available amines, 2′-hydroxyacetophenones, aldehydes, and benzonitriles and could be exploited in drug-discovery campaigns for the rapid identification of biologically active hit compounds.

Original language	English
Pages (from-to)	1464-1467
Journal	Tetrahedron Letters
Volume	57
Issue number	13
Early online date	17 Feb 2016
DOIs	https://doi.org/10.1016/j.tetlet.2016.02.068
Publication status	Published - 30 Mar 2016

Keywords

Multicomponent reaction
Benzofuran
Microwave
Combinatorial chemistry

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10.1016/j.tetlet.2016.02.068

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abstract = "A fast, versatile and practical microwave-assisted multicomponent protocol for the synthesis of substituted benzofuran-2-carboxamides has been developed. The present method proved to be effective on a series of commercially available amines, 2′-hydroxyacetophenones, aldehydes, and benzonitriles and could be exploited in drug-discovery campaigns for the rapid identification of biologically active hit compounds.",

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AU - Scalacci, Nicolò

AU - Costantino, Gabriele

AU - Castagnolo, Daniele

AU - Radi, Marco

PY - 2016/3/30

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AB - A fast, versatile and practical microwave-assisted multicomponent protocol for the synthesis of substituted benzofuran-2-carboxamides has been developed. The present method proved to be effective on a series of commercially available amines, 2′-hydroxyacetophenones, aldehydes, and benzonitriles and could be exploited in drug-discovery campaigns for the rapid identification of biologically active hit compounds.

KW - Multicomponent reaction

KW - Benzofuran

KW - Microwave

KW - Combinatorial chemistry

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M3 - Article

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A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

Abstract

Keywords

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