The objective of this paper is to propose a new hybrid methodology according to near surface mounted (NSM) technique, using carbon fiber reinforced polymer (CFRP) reinforcement for the flexural strengthening of reinforced concrete (RC) beams. This NSM hybrid flexural strengthening technique combines non-prestressed and prestressed CFRP laminates in the same application in order to provide a good balance in terms of load-carrying and ultimate displacement capacity to the strengthened elements. An experimental program composed of six RC beams was carried out to assess the benefits of this NSM hybrid technique when compared to the use of non-prestressed or prestressed NSM CFRP laminates (NSM prestressing technique). For this purpose, the performance of both techniques in terms of crack width, prevailing failure mode, ultimate displacement capacity, energy absorption, and load-carrying capacity of the strengthened beams was assessed. The experimental tests were also simulated by executing advanced 3D nonlinear finite element analysis. Moreover, the potentialities of other configurations for the NSM hybrid technique by adopting different non-prestressed CFRP reinforcement ratios were numerically assessed executing a parametric study, and the relevant results are presented and discussed.