A Rapid Synthetic Approach to the ABCD Core of the Stemona Alkaloids

Rickki Connelly, Jonathan Knowles, Kevin Booker-Milburn

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
3 Downloads (Pure)

Abstract

A new Lewis acid-assisted Brønsted acid cascade approach for the stereoselective formation of the tetracyclic Stemona alkaloid skeleton is described in five steps from epoxide 15. Crucially, this tetracyclic product can be accessed as either C13 epimer, potentially serving as intermediates for the synthesis of a range of Stemona alkaloids.
Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalOrganic Letters
Volume21
Issue number1
Early online date18 Dec 2018
DOIs
Publication statusPublished - 4 Jan 2019

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