A study of clinical and physiological relations of daily physical activity in precapillary pulmonary hypertension

Marios Panagiotou; Martin Johnson; Zafeiris Louvaris; Julien Baker; Alistair Church; Andrew Peacock; Ioannis Vogiatzis

doi:10.1152/japplphysiol.00986.2016

A study of clinical and physiological relations of daily physical activity in precapillary pulmonary hypertension

Marios Panagiotou, Martin Johnson, Zafeiris Louvaris, Julien Baker, Alistair Church, Andrew Peacock, Ioannis Vogiatzis

Sport Exercise and Rehabilitation Department

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Abstract

Daily physical activity is reduced in precapillary pulmonary hypertension (PH) but the underlying mechanisms are inadequately explored. We sought to investigate clinical and physiological relations of daily physical activity and profile differences between less and more active patients with precapillary PH. A prospective, cross-sectional study of 20 patients with precapillary PH who undertook a) a comprehensive clinical assessment, b) a preliminary treadmill test, c) 7-day monitoring of daily walking intensity with triaxial accelerometry and d) a personalized treadmill test corresponding to the individual patient mean daily walking intensity with real-time physiological measurements. Significant clinical correlations with individual patient mean walking intensity (1.71±0.27 m/s2) were observed for log N-terminal pro-brain natriuretic peptide (log-NTproBNP: r=-.75, p=

Original language	English
Pages (from-to)	851-859
Number of pages	9
Journal	Journal of Applied Physiology
Volume	123
Issue number	4
Early online date	29 Jun 2017
DOIs	https://doi.org/10.1152/japplphysiol.00986.2016
Publication status	Published - 1 Oct 2017

Keywords

pulmonary arterial hypertension
daily physical activity
skeletal muscle oxygenation
right ventricle

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Panagiotou et al - daily physical activity in precapillary pulmonary hypertension (JAP 2017)Accepted author manuscript, 937 KB

https://doi.org/10.1152/japplphysiol.00986.2016

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AU - Peacock, Andrew

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A study of clinical and physiological relations of daily physical activity in precapillary pulmonary hypertension

Abstract

Keywords

UN SDGs

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