A study of clinical and physiological relations of daily physical activity in precapillary pulmonary hypertension

Marios Panagiotou, Martin Johnson, Zafeiris Louvaris, Julien Baker, Alistair Church, Andrew Peacock, Ioannis Vogiatzis

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
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Abstract

Daily physical activity is reduced in precapillary pulmonary hypertension (PH) but the underlying mechanisms are inadequately explored. We sought to investigate clinical and physiological relations of daily physical activity and profile differences between less and more active patients with precapillary PH. A prospective, cross-sectional study of 20 patients with precapillary PH who undertook a) a comprehensive clinical assessment, b) a preliminary treadmill test, c) 7-day monitoring of daily walking intensity with triaxial accelerometry and d) a personalized treadmill test corresponding to the individual patient mean daily walking intensity with real-time physiological measurements. Significant clinical correlations with individual patient mean walking intensity (1.71±0.27 m/s2) were observed for log N-terminal pro-brain natriuretic peptide (log-NTproBNP: r=-.75, p=
Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalJournal of Applied Physiology
Volume123
Issue number4
Early online date29 Jun 2017
DOIs
Publication statusPublished - 1 Oct 2017

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