A Surface Acoustic Wave-Based Immunosensing Device Using a Nanocrystalline ZnO Film on Si

Dae-Sik Lee; Jun Hwang Lee; Jikui Luo; Yong Qing Fu; William Milne; Sunglyul Maeng; Mun Yeon Jung; Sun Hee Park; Hyun Yoon

doi:10.1166/jnn.2009.1662

A Surface Acoustic Wave-Based Immunosensing Device Using a Nanocrystalline ZnO Film on Si

Dae-Sik Lee, Jun Hwang Lee, Jikui Luo, Yong Qing Fu, William Milne, Sunglyul Maeng, Mun Yeon Jung, Sun Hee Park, Hyun Yoon

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The novelty of this study resides in the fabrication of a bio-sensing device, based on the surface acoustic wave (SAW) on a nanocrystalline ZnO film. The ZnO film was deposited using an rf magnetron sputtering at room temperature on silicon. The deposited films showed the c-axis-oriented crystallite with grain size of ∼40 nm. The immunosensing device was fabricated using photolithographic protocols on the film. As a model biomolecular recognition and immunosensing, biospecific interaction between a 6-(2,4-dinitrophenyl)aminohexanoic acid (DNP) antigen and its antibody was employed, demonstrating the shifts of resonant frequencies on SAW immunosensing device. The device exhibited a linearity as a function of the antibody concentration in the range of 20∼20,000 ng/ml.

Original language	English
Pages (from-to)	7181-7185
Journal	Journal of Nanoscience and Nanotechnology
Volume	9
Issue number	12
DOIs	https://doi.org/10.1166/jnn.2009.1662
Publication status	Published - Dec 2009

Keywords

DNP
immunosensing
nanocrystalline ZNO
SAW
ZNO/SI

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10.1166/jnn.2009.1662

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title = "A Surface Acoustic Wave-Based Immunosensing Device Using a Nanocrystalline ZnO Film on Si",

abstract = "The novelty of this study resides in the fabrication of a bio-sensing device, based on the surface acoustic wave (SAW) on a nanocrystalline ZnO film. The ZnO film was deposited using an rf magnetron sputtering at room temperature on silicon. The deposited films showed the c-axis-oriented crystallite with grain size of ∼40 nm. The immunosensing device was fabricated using photolithographic protocols on the film. As a model biomolecular recognition and immunosensing, biospecific interaction between a 6-(2,4-dinitrophenyl)aminohexanoic acid (DNP) antigen and its antibody was employed, demonstrating the shifts of resonant frequencies on SAW immunosensing device. The device exhibited a linearity as a function of the antibody concentration in the range of 20∼20,000 ng/ml.",

keywords = "DNP, immunosensing, nanocrystalline ZNO, SAW, ZNO/SI",

author = "Dae-Sik Lee and Lee, \{Jun Hwang\} and Jikui Luo and Fu, \{Yong Qing\} and William Milne and Sunglyul Maeng and Jung, \{Mun Yeon\} and Park, \{Sun Hee\} and Hyun Yoon",

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doi = "10.1166/jnn.2009.1662",

language = "English",

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AU - Lee, Dae-Sik

AU - Lee, Jun Hwang

AU - Luo, Jikui

AU - Fu, Yong Qing

AU - Milne, William

AU - Maeng, Sunglyul

AU - Jung, Mun Yeon

AU - Park, Sun Hee

AU - Yoon, Hyun

PY - 2009/12

Y1 - 2009/12

N2 - The novelty of this study resides in the fabrication of a bio-sensing device, based on the surface acoustic wave (SAW) on a nanocrystalline ZnO film. The ZnO film was deposited using an rf magnetron sputtering at room temperature on silicon. The deposited films showed the c-axis-oriented crystallite with grain size of ∼40 nm. The immunosensing device was fabricated using photolithographic protocols on the film. As a model biomolecular recognition and immunosensing, biospecific interaction between a 6-(2,4-dinitrophenyl)aminohexanoic acid (DNP) antigen and its antibody was employed, demonstrating the shifts of resonant frequencies on SAW immunosensing device. The device exhibited a linearity as a function of the antibody concentration in the range of 20∼20,000 ng/ml.

AB - The novelty of this study resides in the fabrication of a bio-sensing device, based on the surface acoustic wave (SAW) on a nanocrystalline ZnO film. The ZnO film was deposited using an rf magnetron sputtering at room temperature on silicon. The deposited films showed the c-axis-oriented crystallite with grain size of ∼40 nm. The immunosensing device was fabricated using photolithographic protocols on the film. As a model biomolecular recognition and immunosensing, biospecific interaction between a 6-(2,4-dinitrophenyl)aminohexanoic acid (DNP) antigen and its antibody was employed, demonstrating the shifts of resonant frequencies on SAW immunosensing device. The device exhibited a linearity as a function of the antibody concentration in the range of 20∼20,000 ng/ml.

KW - DNP

KW - immunosensing

KW - nanocrystalline ZNO

KW - SAW

KW - ZNO/SI

UR - https://www.scopus.com/pages/publications/70350247851

U2 - 10.1166/jnn.2009.1662

DO - 10.1166/jnn.2009.1662

M3 - Article

SN - 1533-4880

VL - 9

SP - 7181

EP - 7185

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 12

ER -

A Surface Acoustic Wave-Based Immunosensing Device Using a Nanocrystalline ZnO Film on Si

Abstract

Keywords

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