A systematic review of non-pharmacological interventions for primary Sjögren's syndrome

Katie Hackett, Katherine Deane, Victoria Strassheim, Vincent Deary, Tim Rapley, Julia Newton, Wan-Fai Ng

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)
19 Downloads (Pure)


OBJECTIVE: To evaluate the effects of non-pharmacological interventions for primary SS (pSS) on outcomes falling within the World Health Organization International Classification of Functioning Disability and Health domains.

METHODS: We searched the following databases from inception to September 2014: Cochrane Database of Systematic Reviews; Medline; Embase; PsychINFO; CINAHL; and clinical trials registers. We included randomized controlled trials of any non-pharmacological intervention. Two authors independently reviewed titles and abstracts against the inclusion/exclusion criteria and independently assessed trial quality and extracted data.

RESULTS: A total of 1463 studies were identified, from which 17 full text articles were screened and 5 studies were included in the review; a total of 130 participants were randomized. The included studies investigated the effectiveness of an oral lubricating device for dry mouth, acupuncture for dry mouth, lacrimal punctum plugs for dry eyes and psychodynamic group therapy for coping with symptoms. Overall, the studies were of low quality and at high risk of bias. Although one study showed punctum plugs to improve dry eyes, the sample size was relatively small.

CONCLUSION: Further high-quality studies to evaluate non-pharmacological interventions for PSS are needed.

Original languageEnglish
Pages (from-to)2025-2032
Number of pages8
JournalRheumatology (United Kingdom)
Issue number11
Early online date30 Jun 2015
Publication statusPublished - 1 Nov 2015


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