Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

Alan J. Metcalfe, Christina Koliamitra, Florian Javelle, Wilhelm Bloch, Philipp Zimmer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

Original languageEnglish
Pages (from-to)583-587
Number of pages5
JournalPhysiology and Behavior
Volume194
Early online date19 Jul 2018
DOIs
Publication statusPublished - 1 Oct 2018

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