Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

Alan J. Metcalfe; Christina Koliamitra; Florian Javelle; Wilhelm Bloch; Philipp Zimmer

doi:10.1016/j.physbeh.2018.07.015

Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

Alan J. Metcalfe, Christina Koliamitra, Florian Javelle, Wilhelm Bloch, Philipp Zimmer^*

^*Corresponding author for this work

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

Original language	English
Pages (from-to)	583-587
Number of pages	5
Journal	Physiology and Behavior
Volume	194
Early online date	19 Jul 2018
DOIs	https://doi.org/10.1016/j.physbeh.2018.07.015
Publication status	Published - 1 Oct 2018

Keywords

Exercise
Immunology
Physiology
Tryptophan

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10.1016/j.physbeh.2018.07.015

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title = "Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives",

abstract = "Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.",

keywords = "Exercise, Immunology, Physiology, Tryptophan",

author = "Metcalfe, {Alan J.} and Christina Koliamitra and Florian Javelle and Wilhelm Bloch and Philipp Zimmer",

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T1 - Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

AU - Metcalfe, Alan J.

AU - Koliamitra, Christina

AU - Javelle, Florian

AU - Bloch, Wilhelm

AU - Zimmer, Philipp

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

AB - Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

KW - Exercise

KW - Immunology

KW - Physiology

KW - Tryptophan

U2 - 10.1016/j.physbeh.2018.07.015

DO - 10.1016/j.physbeh.2018.07.015

M3 - Review article

C2 - 30031753

AN - SCOPUS:85050275872

SN - 0031-9384

VL - 194

SP - 583

EP - 587

JO - Physiology and Behavior

JF - Physiology and Behavior

ER -

Acute and chronic effects of exercise on the kynurenine pathway in humans – A brief review and future perspectives

Abstract

Keywords

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