Acute thoracoabdominal and hemodynamic responses to tapered flow resistive loading in healthy adults

James Manifield*, Nikolaos Chynkiamis, Charikleia Alexiou, Dimitrios Megaritis, Emily Hume, Gill Barry, Ioannis Vogiatzis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the acute physiological responses of tapered flow resistive loading (TFRL) at 30, 50 and 70% maximal inspiratory pressure (PImax) in 12 healthy adults to determine an optimal resistive load. Increased end-inspiratory rib cage and decreased end-expiratory abdominal volumes equally contributed to the expansion of thoracoabdominal tidal volume (captured by optoelectronic plethysmography). A significant decrease in end-expiratory thoracoabdominal volume was observed from 30 to 50% PImax, from 30 to 70% PImax, and from 50 to 70% PImax. Cardiac output (recorded by cardio-impedance) increased from rest by 30% across the three loading trials. Borg dyspnoea increased from 2.36 ± 0.20 at 30% PImax, to 3.45 ± 0.21 at 50% PImax, and 4.91 ± 0.25 at 70% PImax. End-tidal CO2 decreased from rest during 30, 50 and 70 %PImax (26.23 ± 0.59, 25.87 ± 1.02 and 24.30 ± 0.82 mmHg, respectively). Optimal intensity for TFRL is at 50% PImax to maximise global respiratory muscle and cardiovascular loading whilst minimising hyperventilation and breathlessness.
Original languageEnglish
Article number103617
Number of pages12
JournalRespiratory Physiology and Neurobiology
Volume286
Early online date14 Jan 2021
DOIs
Publication statusPublished - Apr 2021

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