TY - JOUR
T1 - Aging and longevity. A paradigm of complementation between homeostatic mechanisms and genetic control?
AU - Petropoulou, Chariklia
AU - Chondrogianni, Niki
AU - Simões, Davina
AU - Agiostratidou, Georgia
AU - Drosopoulos, Natalia
AU - Kotsota, Violetta
AU - Gonos, Efstathios S.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - Aging is a universal and inevitable phenomenon that affects nearly all animal species. It can be considered the product of an interaction between genetic, environmental, and lifestyle factors, which in turn influence longevity that varies between and within species. It has been proposed not only that the aging process is under genetic control, but that it can also be considered a result of the failure of homeostasis due to the accumulation of damage. This review article discusses these issues, focusing on the function of genes that associate with aging and longevity, as well as on the molecular mechanisms that control cell survival and maintenance during aging.
AB - Aging is a universal and inevitable phenomenon that affects nearly all animal species. It can be considered the product of an interaction between genetic, environmental, and lifestyle factors, which in turn influence longevity that varies between and within species. It has been proposed not only that the aging process is under genetic control, but that it can also be considered a result of the failure of homeostasis due to the accumulation of damage. This review article discusses these issues, focusing on the function of genes that associate with aging and longevity, as well as on the molecular mechanisms that control cell survival and maintenance during aging.
UR - http://www.scopus.com/inward/record.url?scp=0033927992&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2000.tb06642.x
DO - 10.1111/j.1749-6632.2000.tb06642.x
M3 - Article
C2 - 10911954
AN - SCOPUS:0033927992
SN - 0077-8923
VL - 908
SP - 133
EP - 142
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -