Alkyne-enol ether cross-metathesis in the presence of CuSO4: Direct formation of 3-substituted crotonaldehydes in aqueous medium

Daniele Castagnolo, Lorenzo Botta, Maurizio Botta

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25 Citations (Scopus)

Abstract

An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO4 and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making this approach safer, economic, and desiderable from an enviromental point of view.
Original languageEnglish
Pages (from-to)3172-3174
JournalThe Journal of Organic Chemistry
Volume74
Issue number8
DOIs
Publication statusPublished - 2009

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