AltitudeOmics: exercise-induced supraspinal fatigue is
attenuated in healthy humans after acclimatization to high
altitude

Stuart Goodall; Rosie Twomey; Markus Amann; Emma Ross; Andrew Lovering; Lee Romer; Andrew Subudhi; Robert Roach

doi:10.1111/apha.12241

AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude

Stuart Goodall^*, Rosie Twomey, Markus Amann, Emma Ross, Andrew Lovering, Lee Romer, Andrew Subudhi, Robert Roach

^*Corresponding author for this work

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Aims: We asked whether acclimatisation to chronic hypoxia (CH) attenuates the level of supraspinal fatigue that is observed after locomotor exercise in acute hypoxia (AH). Methods: Seven recreationally-active participants performed identical bouts of constant-load cycling (131±39W, 10.1±1.4min) on three occasions: 1) in normoxia (N, PIO2, 147.1mmHg); 2) in AH (FIO2, 0.105; PIO2, 73.8mmHg); 3) after 14 days in CH (5,260m; PIO2, 75.7mmHg). Throughout trials, prefrontal-cortex tissue oxygenation and middle cerebral artery blood velocity (MCAV) were assessed using near-infrared-spectroscopy and transcranial Doppler sonography. Pre- and post-exercise twitch responses to femoral nerve stimulation and transcranial magnetic stimulation were obtained to assess neuromuscular and corticospinal function. Results: In AH, prefrontal oxygenation declined at rest (Δ7±5%) and end-exercise (Δ26±13) (P

Original language	English
Pages (from-to)	875-888
Journal	Acta Physiologica
Volume	210
Issue number	4
Early online date	22 Jan 2014
DOIs	https://doi.org/10.1111/apha.12241
Publication status	Published - 14 Mar 2014

Keywords

adaptation
altitude
exercise
transcranial magnetic stimulation

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10.1111/apha.12241

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title = "AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude",

abstract = "Aims: We asked whether acclimatisation to chronic hypoxia (CH) attenuates the level of supraspinal fatigue that is observed after locomotor exercise in acute hypoxia (AH). Methods: Seven recreationally-active participants performed identical bouts of constant-load cycling (131±39W, 10.1±1.4min) on three occasions: 1) in normoxia (N, PIO2, 147.1mmHg); 2) in AH (FIO2, 0.105; PIO2, 73.8mmHg); 3) after 14 days in CH (5,260m; PIO2, 75.7mmHg). Throughout trials, prefrontal-cortex tissue oxygenation and middle cerebral artery blood velocity (MCAV) were assessed using near-infrared-spectroscopy and transcranial Doppler sonography. Pre- and post-exercise twitch responses to femoral nerve stimulation and transcranial magnetic stimulation were obtained to assess neuromuscular and corticospinal function. Results: In AH, prefrontal oxygenation declined at rest (Δ7±5%) and end-exercise (Δ26±13) (P",

keywords = "adaptation, altitude, exercise, transcranial magnetic stimulation",

author = "Stuart Goodall and Rosie Twomey and Markus Amann and Emma Ross and Andrew Lovering and Lee Romer and Andrew Subudhi and Robert Roach",

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doi = "10.1111/apha.12241",

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T1 - AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude

AU - Goodall, Stuart

AU - Twomey, Rosie

AU - Amann, Markus

AU - Ross, Emma

AU - Lovering, Andrew

AU - Romer, Lee

AU - Subudhi, Andrew

AU - Roach, Robert

N1 - Published online first before print 14 March 2014.

PY - 2014/3/14

Y1 - 2014/3/14

N2 - Aims: We asked whether acclimatisation to chronic hypoxia (CH) attenuates the level of supraspinal fatigue that is observed after locomotor exercise in acute hypoxia (AH). Methods: Seven recreationally-active participants performed identical bouts of constant-load cycling (131±39W, 10.1±1.4min) on three occasions: 1) in normoxia (N, PIO2, 147.1mmHg); 2) in AH (FIO2, 0.105; PIO2, 73.8mmHg); 3) after 14 days in CH (5,260m; PIO2, 75.7mmHg). Throughout trials, prefrontal-cortex tissue oxygenation and middle cerebral artery blood velocity (MCAV) were assessed using near-infrared-spectroscopy and transcranial Doppler sonography. Pre- and post-exercise twitch responses to femoral nerve stimulation and transcranial magnetic stimulation were obtained to assess neuromuscular and corticospinal function. Results: In AH, prefrontal oxygenation declined at rest (Δ7±5%) and end-exercise (Δ26±13) (P

AB - Aims: We asked whether acclimatisation to chronic hypoxia (CH) attenuates the level of supraspinal fatigue that is observed after locomotor exercise in acute hypoxia (AH). Methods: Seven recreationally-active participants performed identical bouts of constant-load cycling (131±39W, 10.1±1.4min) on three occasions: 1) in normoxia (N, PIO2, 147.1mmHg); 2) in AH (FIO2, 0.105; PIO2, 73.8mmHg); 3) after 14 days in CH (5,260m; PIO2, 75.7mmHg). Throughout trials, prefrontal-cortex tissue oxygenation and middle cerebral artery blood velocity (MCAV) were assessed using near-infrared-spectroscopy and transcranial Doppler sonography. Pre- and post-exercise twitch responses to femoral nerve stimulation and transcranial magnetic stimulation were obtained to assess neuromuscular and corticospinal function. Results: In AH, prefrontal oxygenation declined at rest (Δ7±5%) and end-exercise (Δ26±13) (P

KW - adaptation

KW - altitude

KW - exercise

KW - transcranial magnetic stimulation

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DO - 10.1111/apha.12241

M3 - Article

SN - 1748-1708

VL - 210

SP - 875

EP - 888

JO - Acta Physiologica

JF - Acta Physiologica

IS - 4

ER -

AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude

Abstract

Keywords

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