Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

Kieren J. Egan; Hadassa Campos Santos; Felipe Beijamini; Núbia E. Duarte; Andréa R.V.R. Horimoto; Tâmara P. Taporoski; Homero Vallada; André B. Negrão; José E. Krieger; Mário Pedrazzoli; Kristen L. Knutson; Alexandre C. Pereira; Malcolm von Schantz

doi:10.1080/07420528.2016.1265979

Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

Kieren J. Egan, Hadassa Campos Santos, Felipe Beijamini, Núbia E. Duarte, Andréa R.V.R. Horimoto, Tâmara P. Taporoski, Homero Vallada, André B. Negrão, José E. Krieger, Mário Pedrazzoli, Kristen L. Knutson, Alexandre C. Pereira, Malcolm von Schantz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness–eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Chronobiology International
Volume	34
Issue number	2
Early online date	5 Jan 2017
DOIs	https://doi.org/10.1080/07420528.2016.1265979
Publication status	Published - 7 Feb 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality

Keywords

Admixture
American Native Continental Ancestry Group
Brazil
chronotype
circadian rhythm
diurnal preference
sleep homeostasis

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10.1080/07420528.2016.1265979

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Egan, K. J., Campos Santos, H., Beijamini, F., Duarte, N. E., Horimoto, A. R. V. R., Taporoski, T. P., Vallada, H., Negrão, A. B., Krieger, J. E., Pedrazzoli, M., Knutson, K. L., Pereira, A. C., & von Schantz, M. (2017). Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population. Chronobiology International, 34(2), 269-272. https://doi.org/10.1080/07420528.2016.1265979

@article{80426de9506a4961ba3bfb50852047e0,

title = "Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population",

abstract = "Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness–eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.",

keywords = "Admixture, American Native Continental Ancestry Group, Brazil, chronotype, circadian rhythm, diurnal preference, sleep homeostasis",

author = "Egan, \{Kieren J.\} and \{Campos Santos\}, Hadassa and Felipe Beijamini and Duarte, \{N{\'u}bia E.\} and Horimoto, \{Andr{\'e}a R.V.R.\} and Taporoski, \{T{\^a}mara P.\} and Homero Vallada and Negr{\~a}o, \{Andr{\'e} B.\} and Krieger, \{Jos{\'e} E.\} and M{\'a}rio Pedrazzoli and Knutson, \{Kristen L.\} and Pereira, \{Alexandre C.\} and \{von Schantz\}, Malcolm",

note = "This study was supported by awards from CNPq to HV and MvS (400791/2015-5), and by the Global Innovation Initiative to MvS (jointly funded by the British Council and the UK Department of Business and Skills). The data collection was supported by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP 2012/05447-0; 2012/12042-7; 2013-17368-0), and PROADI\_ SUS (25000.180664/2011-35).",

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month = feb,

day = "7",

doi = "10.1080/07420528.2016.1265979",

language = "English",

volume = "34",

pages = "269--272",

journal = "Chronobiology International",

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Egan, KJ, Campos Santos, H, Beijamini, F, Duarte, NE, Horimoto, ARVR, Taporoski, TP, Vallada, H, Negrão, AB, Krieger, JE, Pedrazzoli, M, Knutson, KL, Pereira, AC & von Schantz, M 2017, 'Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population', Chronobiology International, vol. 34, no. 2, pp. 269-272. https://doi.org/10.1080/07420528.2016.1265979

TY - JOUR

T1 - Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

AU - Egan, Kieren J.

AU - Campos Santos, Hadassa

AU - Beijamini, Felipe

AU - Duarte, Núbia E.

AU - Horimoto, Andréa R.V.R.

AU - Taporoski, Tâmara P.

AU - Vallada, Homero

AU - Negrão, André B.

AU - Krieger, José E.

AU - Pedrazzoli, Mário

AU - Knutson, Kristen L.

AU - Pereira, Alexandre C.

AU - von Schantz, Malcolm

N1 - This study was supported by awards from CNPq to HV and MvS (400791/2015-5), and by the Global Innovation Initiative to MvS (jointly funded by the British Council and the UK Department of Business and Skills). The data collection was supported by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP 2012/05447-0; 2012/12042-7; 2013-17368-0), and PROADI_ SUS (25000.180664/2011-35).

PY - 2017/2/7

Y1 - 2017/2/7

N2 - Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness–eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.

AB - Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness–eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.

KW - Admixture

KW - American Native Continental Ancestry Group

KW - Brazil

KW - chronotype

KW - circadian rhythm

KW - diurnal preference

KW - sleep homeostasis

UR - https://www.scopus.com/pages/publications/85008410773

U2 - 10.1080/07420528.2016.1265979

DO - 10.1080/07420528.2016.1265979

M3 - Article

C2 - 28055282

AN - SCOPUS:85008410773

SN - 0742-0528

VL - 34

SP - 269

EP - 272

JO - Chronobiology International

JF - Chronobiology International

IS - 2

ER -

Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

Abstract

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Keywords

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