TY - JOUR
T1 - Amoxicillin-laded sodium alginate/cellulose nanocrystals/polyvinyl alcohol composite nanonetwork sponges with enhanced wound healing and antibacterial performance
AU - Qi, Houjuan
AU - Yang, Lifei
AU - Ma, Rongxiu
AU - Xiang, Yushuang
AU - Dai, Yuxin
AU - Ren, Juanna
AU - Xu, Ben Bin
AU - El-Bahy, Zeinhom M.
AU - Thabet, Hamdy Khamees
AU - Huang, Zhanhua
AU - Ben, Wei
AU - Yu, Huimin
AU - Guo, Zhanhu
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Wound healing is a complex process and reuires a long repair process. Poor healing effect is normally a challenge for wound healing. Designing sponge dressings with drug-assisted therapy, good breathability, and multiple functional structures effectively promotes wound healing. In this work, a flexible amoxicillin-laded (AMX) sodium alginate (SA)/cellulose nanocrystals (CNCs)/ polyvinyl alcoho (PVA) (SA/CNCs/PVA-AMX, SCP-AMX) wound dressing was designed and built with an excellent porous structure, suitable porosity, and anti-bacterial properties for promoting wound tissue reparation. The porous structure of the wound dressing was fabricated by freeze-thawing cyclic and freeze-dried molding process. This wound dressing exhibited a 3D porous structure for soft-tissue-engineering application, including high porosity (84.2%), swelling ratio (1513%), tensile strength (1.79 MPA), and flexibility. With the inhibition zones of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) being 1.96 and4.58 cm, respectively, this wound dressing demonstrated good antibacterial activity against E. coli and S. aureus. More importantly, wound healing assay in vivo indicates that SCP-AMX could inhibit wound infection, promote collagen deposition, reduce inflammation, and accelerate granulation tissue and wound healing. Thus, the reported wounding dressings present excellent biocompatibility, high antibacterial activities, and excellent biosafety with great potential in wound healing applications.
AB - Wound healing is a complex process and reuires a long repair process. Poor healing effect is normally a challenge for wound healing. Designing sponge dressings with drug-assisted therapy, good breathability, and multiple functional structures effectively promotes wound healing. In this work, a flexible amoxicillin-laded (AMX) sodium alginate (SA)/cellulose nanocrystals (CNCs)/ polyvinyl alcoho (PVA) (SA/CNCs/PVA-AMX, SCP-AMX) wound dressing was designed and built with an excellent porous structure, suitable porosity, and anti-bacterial properties for promoting wound tissue reparation. The porous structure of the wound dressing was fabricated by freeze-thawing cyclic and freeze-dried molding process. This wound dressing exhibited a 3D porous structure for soft-tissue-engineering application, including high porosity (84.2%), swelling ratio (1513%), tensile strength (1.79 MPA), and flexibility. With the inhibition zones of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) being 1.96 and4.58 cm, respectively, this wound dressing demonstrated good antibacterial activity against E. coli and S. aureus. More importantly, wound healing assay in vivo indicates that SCP-AMX could inhibit wound infection, promote collagen deposition, reduce inflammation, and accelerate granulation tissue and wound healing. Thus, the reported wounding dressings present excellent biocompatibility, high antibacterial activities, and excellent biosafety with great potential in wound healing applications.
KW - Composite sponge
KW - Antibacterial activity
KW - Wound healing
UR - https://www.scopus.com/pages/publications/85204383781
U2 - 10.1016/j.ijbiomac.2024.135701
DO - 10.1016/j.ijbiomac.2024.135701
M3 - Article
SN - 0141-8130
VL - 280
SP - 1
EP - 10
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
IS - Pt 1
M1 - 135701
ER -