An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Fangda Wu, Ming Hong Shen, Jian Yang, Hanlin Wang, Roman Mikhaylov, Aled Clayton, Xinghua Qin, Chao Sun, Zhihua Xie, Meng Cai, Jun Wei, Dongfang Liang, Fan Yuan, Zhenlin Wu, Richard Fu, Zhiyong Yang, Xianfang Sun, Liangfei Tian, Xin Yang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
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Abstract

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.
Original languageEnglish
Article number9363916
Pages (from-to)577-580
Number of pages4
JournalIEEE Electron Device Letters
Volume42
Issue number4
Early online date26 Feb 2021
DOIs
Publication statusPublished - 1 Apr 2021

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