An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Fangda Wu; Ming Hong Shen; Jian Yang; Hanlin Wang; Roman Mikhaylov; Aled Clayton; Xinghua Qin; Chao Sun; Zhihua Xie; Meng Cai; Jun Wei; Dongfang Liang; Fan Yuan; Zhenlin Wu; Richard Fu; Zhiyong Yang; Xianfang Sun; Liangfei Tian; Xin Yang

doi:10.1109/led.2021.3062292

An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Fangda Wu, Ming Hong Shen, Jian Yang, Hanlin Wang, Roman Mikhaylov, Aled Clayton, Xinghua Qin, Chao Sun, Zhihua Xie, Meng Cai, Jun Wei, Dongfang Liang, Fan Yuan, Zhenlin Wu, Richard Fu, Zhiyong Yang, Xianfang Sun, Liangfei Tian, Xin Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

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Abstract

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

Original language	English
Article number	9363916
Pages (from-to)	577-580
Number of pages	4
Journal	IEEE Electron Device Letters
Volume	42
Issue number	4
Early online date	26 Feb 2021
DOIs	https://doi.org/10.1109/led.2021.3062292
Publication status	Published - 1 Apr 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

Keywords

Surface acoustic wave (SAW)
acoustic separation
acoustofluidics
cancer cells

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10.1109/led.2021.3062292

FINAL VERSIONAccepted author manuscript, 1.8 MB

Cite this

Wu, F., Shen, M. H., Yang, J., Wang, H., Mikhaylov, R., Clayton, A., Qin, X., Sun, C., Xie, Z., Cai, M., Wei, J., Liang, D., Yuan, F., Wu, Z., Fu, R., Yang, Z., Sun, X., Tian, L., & Yang, X. (2021). An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. IEEE Electron Device Letters, 42(4), 577-580. Article 9363916. https://doi.org/10.1109/led.2021.3062292

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title = "An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation",

abstract = "In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32\% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.",

keywords = "Surface acoustic wave (SAW), acoustic separation, acoustofluidics, cancer cells",

author = "Fangda Wu and Shen, \{Ming Hong\} and Jian Yang and Hanlin Wang and Roman Mikhaylov and Aled Clayton and Xinghua Qin and Chao Sun and Zhihua Xie and Meng Cai and Jun Wei and Dongfang Liang and Fan Yuan and Zhenlin Wu and Richard Fu and Zhiyong Yang and Xianfang Sun and Liangfei Tian and Xin Yang",

note = "Funding information: This work was supported in part by the Natural Science Basic Research Program of Shaanxi Province under Grant 2020JQ-233, in part by the Fundamental Scientific Research of Central Universities under Grant 3102017OQD116, in part by the Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/P002803/1 and Grant EP/P018998/1, and in part by the Royal Society under Grant IEC/NSFC/170142 and Grant IE161019.",

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AU - Mikhaylov, Roman

AU - Clayton, Aled

AU - Qin, Xinghua

AU - Sun, Chao

AU - Xie, Zhihua

AU - Cai, Meng

AU - Wei, Jun

AU - Liang, Dongfang

AU - Yuan, Fan

AU - Wu, Zhenlin

AU - Fu, Richard

AU - Yang, Zhiyong

AU - Sun, Xianfang

AU - Tian, Liangfei

AU - Yang, Xin

N1 - Funding information: This work was supported in part by the Natural Science Basic Research Program of Shaanxi Province under Grant 2020JQ-233, in part by the Fundamental Scientific Research of Central Universities under Grant 3102017OQD116, in part by the Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/P002803/1 and Grant EP/P018998/1, and in part by the Royal Society under Grant IEC/NSFC/170142 and Grant IE161019.

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Y1 - 2021/4/1

N2 - In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

AB - In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and microparticles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

KW - Surface acoustic wave (SAW)

KW - acoustic separation

KW - acoustofluidics

KW - cancer cells

UR - https://www.scopus.com/pages/publications/85101862698

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JF - IEEE Electron Device Letters

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M1 - 9363916

ER -

An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Abstract

UN SDGs

Keywords

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