The optimal operation programming of electrical systems through the minimization of the production cost and the market clearing price, as well as the better utilization of renewable energy resources, has attracted the attention ofmany researchers. To reach this aim, energy management systems (EMSs) have been studied in many research activities. Moreover, a demand response (DR) expands customer participation to power systems and results in a paradigm shift from conventional to interactive activities in power systems due to the progress of smart grid technology. Therefore, the modeling of a consumer characteristic in the DR is becoming a very important issue in these systems. The customer information as the registration and participation information of the DR is used to provide additional indexes for evaluating the customer response, such as consumer’s information based on the offer priority, the DR magnitude, the duration, and the minimum cost of energy. In this paper, a multiperiod artificial bee colony optimization algorithm is implemented for economic dispatch considering generation, storage, and responsive load offers. The better performance of the proposed algorithm is shown in comparison with the modified conventional EMS, and its effectiveness is experimentally validated over a microgrid test bed. The obtained results show cost reduction (by around 30%), convergence speed increase, and the remarkable improvement of efficiency and accuracy under uncertain conditions. An artifi- cial neural network combined with a Markov chain (ANN-MC) approach is used to predict nondispatchable power generation and load demand considering uncertainties. Furthermore, other capabilities such as extendibility, reliability, and flexibility are examined about the proposed approach.