The objective of this paper is to propose a simplified analytical approach to predict the flexural behavior of simply supported reinforced-concrete (RC) beams flexurally strengthened with prestressed carbon fiber reinforced polymer (CFRP) reinforcements using either externally bonded reinforcing (EBR) or near surface mounted (NSM) techniques. This design methodology also considers the ultimate flexural capacity of NSM CFRP strengthened beams when concrete cover delamination is the governing failure mode. A moment-curvature (M-χ) relationship formed by three linear branches corresponding to the precracking, postcracking, and postyielding stages is established by considering the four critical M-χ points that characterize the flexural behavior of CFRP strengthened beams. Two additional M-χ points, namely, concrete decompression and steel decompression, are also defined to assess the initial effects of the prestress force applied by the FRP reinforcement. The mid-span deflection of the beams is predicted based on the curvature approach, assuming a linear curvature variation between the critical points along the beam length. The good predictive performance of the analytical model is appraised by simulating the force-deflection response registered in experimental programs composed of RC beams strengthened with prestressed NSM CFRP reinforcements.