Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin

Chen Li; Zhiwei Liu; Song Liu; Santosh K. Tiwari; Kunyapat Thummavichai; Oluwafunmilola Ola; Zhiyuan Ma; Shenghua Zhang; Nannan Wang; Yanqiu Zhu

doi:10.1016/j.apsusc.2022.153132

Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin

Chen Li, Zhiwei Liu, Song Liu, Santosh K. Tiwari, Kunyapat Thummavichai (Editor), Oluwafunmilola Ola, Zhiyuan Ma, Shenghua Zhang^*, Nannan Wang, Yanqiu Zhu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.

Original language	English
Article number	153132
Journal	Applied Surface Science
Volume	590
Early online date	23 Mar 2022
DOIs	https://doi.org/10.1016/j.apsusc.2022.153132
Publication status	Published - 15 Jul 2022
Externally published	Yes

Keywords

Antibacterial
Drug release
Nanofiber
Silver nanoparticles
Wound dressing

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10.1016/j.apsusc.2022.153132

manuscript-v9 (20220209)_markedAccepted author manuscript, 1.27 MBLicence: CC BY-NC-ND

https://nottingham-repository.worktribe.com/output/7676528Licence: CC BY-NC-ND

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@article{0a89e632e6a34ba1b2565a05d0f60cd9,

title = "Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin",

abstract = "In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.",

keywords = "Antibacterial, Drug release, Nanofiber, Silver nanoparticles, Wound dressing",

author = "Chen Li and Zhiwei Liu and Song Liu and Tiwari, \{Santosh K.\} and Kunyapat Thummavichai and Oluwafunmilola Ola and Zhiyuan Ma and Shenghua Zhang and Nannan Wang and Yanqiu Zhu",

note = "Funding Information: This project is supported by Chinese National Natural Science Foundation (No. 51972068 ), Specific Research Project of Guangxi for Research Bases and Talents, China (No. GuiKe AD19245145 ), Natural Science Foundation of Guangxi Province, China (No. 2018GXNSFBA281106 and No. 2021GXNSFBA076003 ). ",

year = "2022",

month = jul,

day = "15",

doi = "10.1016/j.apsusc.2022.153132",

language = "English",

volume = "590",

journal = "Applied Surface Science",

issn = "0169-4332",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin

AU - Li, Chen

AU - Liu, Zhiwei

AU - Liu, Song

AU - Tiwari, Santosh K.

AU - Ola, Oluwafunmilola

AU - Ma, Zhiyuan

AU - Zhang, Shenghua

AU - Wang, Nannan

AU - Zhu, Yanqiu

A2 - Thummavichai, Kunyapat

N1 - Funding Information: This project is supported by Chinese National Natural Science Foundation (No. 51972068 ), Specific Research Project of Guangxi for Research Bases and Talents, China (No. GuiKe AD19245145 ), Natural Science Foundation of Guangxi Province, China (No. 2018GXNSFBA281106 and No. 2021GXNSFBA076003 ).

PY - 2022/7/15

Y1 - 2022/7/15

N2 - In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.

AB - In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.

KW - Antibacterial

KW - Drug release

KW - Nanofiber

KW - Silver nanoparticles

KW - Wound dressing

UR - https://www.scopus.com/pages/publications/85126953527

U2 - 10.1016/j.apsusc.2022.153132

DO - 10.1016/j.apsusc.2022.153132

M3 - Article

AN - SCOPUS:85126953527

SN - 0169-4332

VL - 590

JO - Applied Surface Science

JF - Applied Surface Science

M1 - 153132

ER -

Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin

Abstract

Keywords

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