Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules

Antony N. Antoniou*, Izabela Lenart, David B. Guiliano, Simon J. Powis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

A successful vaccine delivers the pathogenic agent or a component thereof in an immunogenic form, without eliciting the disease pathology, which enables an effective immune response with long-lasting protection. The effectiveness and protection offered by vaccination requires the successful activation of the acquired immune response elicited primarily by thymus (T) and bone marrow (B) derived lymphocytes. Activation of T lymphocytes requires engagement of their specialized T cell receptors with cell surface molecules encoded by the major histocompatibility complex (MHC). These are categorized into MHC class I, class II, and nonclassical molecules. T lymphocytes control the magnitude of their own response and enable a successful B cell response. Therefore, the mechanism of peptide generation (antigen processing) and loading onto MHC molecules (antigen presentation) are pivotal to a successful immune response and effective vaccination, especially when considering the generation of recombinant vaccines.
Original languageEnglish
Title of host publicationVaccinology
Subtitle of host publicationPrinciples and Practice
Place of PublicationOxford
PublisherWiley
Pages29-46
Number of pages18
ISBN (Electronic)9781118345313
ISBN (Print)9781405185745
DOIs
Publication statusPublished - 3 Aug 2012
Externally publishedYes

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