Abstract
Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.
| Original language | English |
|---|---|
| Pages (from-to) | 167-173 |
| Journal | Experimental Dermatology |
| Volume | 25 |
| Issue number | 3 |
| Early online date | 6 Jan 2016 |
| DOIs | |
| Publication status | Published - Mar 2016 |
Keywords
- antibiotic resistance
- antimicrobial peptide
- frog skin
- innate immunity
- skin infections
- wound healing