Abstract
Tissue engineering promises new bone replacement in areas of large defects due to traumatised, damaged or lost bone. One of the bone formation strategies is to construct bio-scaffold, which allows bone reformation, once it is surgically placed in bone-defect. Current issues with manufacturing and designing bio-scaffolds are mechanical strength along with biocompatibility, osteoinductiveness (which allows induction of bone cells), osteoconductiveness (conducive to cell attachment) of materials of the bio-scaffold. This paper explores the combination of biomaterials to form bio-scaffold using 3D Printing rapid prototyping method. Using novel medical application of synthetic Hydroxyapatite with Sol (hydrolyzed ethyl silicate) to form three-dimensional prototypes, the possibility of bio-scaffold manufacturing for hard tissue engineering is studied. Sintered 3D Printed prototypes are assessed for densification (pore size) and strength using bi-axial stress methodology. Osteoinductiveness and osteoconductiveness of both materials with strong binding tendency of Sol-gel seemed more promising in bio-scaffold manufacturing for bone tissue engineering. Conventional 3D Printing methodology and materials are identified to make bio-scaffold structures. Relationships with temperature and catalyst concentration are studied to use these as basic principles for modification of the 3D Printing process.
Original language | English |
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Title of host publication | Fifth National Conference on Rapid Design, Prototyping, and Manufacturing |
Place of Publication | Oxford |
Publisher | Blackwell Publishing |
Pages | 53-60 |
ISBN (Print) | 978-1860584657 |
Publication status | Published - 2004 |
Keywords
- 3D Printing
- bio-scaffold
- bone tissue engineering
- ceramics and porosity
- sol