Application of the Z-Corps three-dimensional printing processes using novel material to manufacture bio-scaffold for bone replacement

Philip Hackney, Ketan Pancholi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Tissue engineering promises new bone replacement in areas of large defects due to traumatised, damaged or lost bone. One of the bone formation strategies is to construct bio-scaffold, which allows bone reformation, once it is surgically placed in bone-defect. Current issues with manufacturing and designing bio-scaffolds are mechanical strength along with biocompatibility, osteoinductiveness (which allows induction of bone cells), osteoconductiveness (conducive to cell attachment) of materials of the bio-scaffold. This paper explores the combination of biomaterials to form bio-scaffold using 3D Printing rapid prototyping method. Using novel medical application of synthetic Hydroxyapatite with Sol (hydrolyzed ethyl silicate) to form three-dimensional prototypes, the possibility of bio-scaffold manufacturing for hard tissue engineering is studied. Sintered 3D Printed prototypes are assessed for densification (pore size) and strength using bi-axial stress methodology. Osteoinductiveness and osteoconductiveness of both materials with strong binding tendency of Sol-gel seemed more promising in bio-scaffold manufacturing for bone tissue engineering. Conventional 3D Printing methodology and materials are identified to make bio-scaffold structures. Relationships with temperature and catalyst concentration are studied to use these as basic principles for modification of the 3D Printing process.
Original languageEnglish
Title of host publicationFifth National Conference on Rapid Design, Prototyping, and Manufacturing
Place of PublicationOxford
PublisherWiley
Pages53-60
ISBN (Print)978-1860584657
Publication statusPublished - 2004

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