Tissue engineering promises new bone replacement in areas of large defects due to traumatised, damaged or lost bone. One of the bone formation strategies is to construct bio-scaffold, which allows bone reformation, once it is surgically placed in bone-defect. Current issues with manufacturing and designing bio-scaffolds are mechanical strength along with biocompatibility, osteoinductiveness (which allows induction of bone cells), osteoconductiveness (conducive to cell attachment) of materials of the bio-scaffold. This paper explores the combination of biomaterials to form bio-scaffold using 3D Printing rapid prototyping method. Using novel medical application of synthetic Hydroxyapatite with Sol (hydrolyzed ethyl silicate) to form three-dimensional prototypes, the possibility of bio-scaffold manufacturing for hard tissue engineering is studied. Sintered 3D Printed prototypes are assessed for densification (pore size) and strength using bi-axial stress methodology. Osteoinductiveness and osteoconductiveness of both materials with strong binding tendency of Sol-gel seemed more promising in bio-scaffold manufacturing for bone tissue engineering. Conventional 3D Printing methodology and materials are identified to make bio-scaffold structures. Relationships with temperature and catalyst concentration are studied to use these as basic principles for modification of the 3D Printing process.
|Title of host publication||Fifth National Conference on Rapid Design, Prototyping, and Manufacturing|
|Place of Publication||Oxford|
|Publication status||Published - 2004|