Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication?: Vascular Parameters and Walking Impairment in PAD

Gustavo Oliveira da Silva; Marilia de Almeida Correia; Paulo Longano Mesquita de Oliveira; Breno Quintella Farah; Lauro C. Vianna; Pedro Puech-Leão; Nelson Wolosker; Gabriel Grizzo Cucato; Raphael Mendes Ritti-Dias

doi:10.1016/j.avsg.2021.06.011

Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication? Vascular Parameters and Walking Impairment in PAD

Gustavo Oliveira da Silva, Marilia de Almeida Correia, Paulo Longano Mesquita de Oliveira, Breno Quintella Farah, Lauro C. Vianna, Pedro Puech-Leão, Nelson Wolosker, Gabriel Grizzo Cucato, Raphael Mendes Ritti-Dias^*

^*Corresponding author for this work

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Article › peer-review

Abstract

Background
The mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations.

Objective
To analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication.

Methods
This was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test [6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire [WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters.

Results
No significant associations between the claudication onset distance (PWV: b=.060, p=.842; FMD: b=-.192, p=.456), 6MWT (PWV: b=.007, p=.975; FMD: b=.090, p=.725), WIQ distance (PWV: b=.337, p=.117; FMD: b=-.025, p=.895) WIQ speed (PWV: b=.320, p=.181; FMD: b=-.028, p=.497), WIQ stairs (PWV: b=.256, p=.204; FMD: b=-.228, p=.230), 4-meter usual walk (PWV: b=-.421, p=.107; FMD: b=-.338, p=.112), 4-meter fast walk (PWV: b=-.496, p=.063; FMD: b=-.371, p=.086) and vascular function were found.

Conclusions
In symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes.

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Annals of Vascular Surgery
Volume	77
Early online date	26 Aug 2021
DOIs	https://doi.org/10.1016/j.avsg.2021.06.011
Publication status	Published - 1 Nov 2021

Keywords

peripheral arterial disease; vascular function; functional capacity; six-minute walk test.
six-minute walk test
functional capacity
vascular function

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.avsg.2021.06.011

Cite this

da Silva, G. O., Correia, M. D. A., de Oliveira, P. L. M., Farah, B. Q., Vianna, L. C., Puech-Leão, P., Wolosker, N., Cucato, G. G., & Ritti-Dias, R. M. (2021). Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication? Vascular Parameters and Walking Impairment in PAD. Annals of Vascular Surgery, 77, 31-37. https://doi.org/10.1016/j.avsg.2021.06.011

@article{f04385c6082e465c813b5320a08470f5,

title = "Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication?: Vascular Parameters and Walking Impairment in PAD",

abstract = "BackgroundThe mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations.ObjectiveTo analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication.MethodsThis was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test [6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire [WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters.ResultsNo significant associations between the claudication onset distance (PWV: b=.060, p=.842; FMD: b=-.192, p=.456), 6MWT (PWV: b=.007, p=.975; FMD: b=.090, p=.725), WIQ distance (PWV: b=.337, p=.117; FMD: b=-.025, p=.895) WIQ speed (PWV: b=.320, p=.181; FMD: b=-.028, p=.497), WIQ stairs (PWV: b=.256, p=.204; FMD: b=-.228, p=.230), 4-meter usual walk (PWV: b=-.421, p=.107; FMD: b=-.338, p=.112), 4-meter fast walk (PWV: b=-.496, p=.063; FMD: b=-.371, p=.086) and vascular function were found.ConclusionsIn symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes.",

keywords = "peripheral arterial disease; vascular function; functional capacity; six-minute walk test., six-minute walk test, functional capacity, vascular function",

author = "{da Silva}, {Gustavo Oliveira} and Correia, {Marilia de Almeida} and {de Oliveira}, {Paulo Longano Mesquita} and Farah, {Breno Quintella} and Vianna, {Lauro C.} and Pedro Puech-Le{\~a}o and Nelson Wolosker and Cucato, {Gabriel Grizzo} and Ritti-Dias, {Raphael Mendes}",

note = "Funding information: Research funded by Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (310508/2017-72016/16425-92019/05221-1) | Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (310508/2017-72016/16425-92019/05221-1) | Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (310508/2017-72016/16425-92019/05221-1).",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.avsg.2021.06.011",

language = "English",

volume = "77",

pages = "31--37",

journal = "Annals of Vascular Surgery",

issn = "0890-5096",

publisher = "Elsevier",

}

Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication? Vascular Parameters and Walking Impairment in PAD. / da Silva, Gustavo Oliveira; Correia, Marilia de Almeida; de Oliveira, Paulo Longano Mesquita et al.
In: Annals of Vascular Surgery, Vol. 77, 01.11.2021, p. 31-37.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Are Vascular Parameters Associated with Walking Impairment in Patients with Claudication?

T2 - Vascular Parameters and Walking Impairment in PAD

AU - da Silva, Gustavo Oliveira

AU - Correia, Marilia de Almeida

AU - de Oliveira, Paulo Longano Mesquita

AU - Farah, Breno Quintella

AU - Vianna, Lauro C.

AU - Puech-Leão, Pedro

AU - Wolosker, Nelson

AU - Cucato, Gabriel Grizzo

AU - Ritti-Dias, Raphael Mendes

N1 - Funding information: Research funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (310508/2017-72016/16425-92019/05221-1) | Conselho Nacional de Desenvolvimento Científico e Tecnológico (310508/2017-72016/16425-92019/05221-1) | Fundação de Amparo à Pesquisa do Estado de São Paulo (310508/2017-72016/16425-92019/05221-1).

PY - 2021/11/1

Y1 - 2021/11/1

N2 - BackgroundThe mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations.ObjectiveTo analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication.MethodsThis was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test [6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire [WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters.ResultsNo significant associations between the claudication onset distance (PWV: b=.060, p=.842; FMD: b=-.192, p=.456), 6MWT (PWV: b=.007, p=.975; FMD: b=.090, p=.725), WIQ distance (PWV: b=.337, p=.117; FMD: b=-.025, p=.895) WIQ speed (PWV: b=.320, p=.181; FMD: b=-.028, p=.497), WIQ stairs (PWV: b=.256, p=.204; FMD: b=-.228, p=.230), 4-meter usual walk (PWV: b=-.421, p=.107; FMD: b=-.338, p=.112), 4-meter fast walk (PWV: b=-.496, p=.063; FMD: b=-.371, p=.086) and vascular function were found.ConclusionsIn symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes.

AB - BackgroundThe mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations.ObjectiveTo analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication.MethodsThis was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test [6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire [WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters.ResultsNo significant associations between the claudication onset distance (PWV: b=.060, p=.842; FMD: b=-.192, p=.456), 6MWT (PWV: b=.007, p=.975; FMD: b=.090, p=.725), WIQ distance (PWV: b=.337, p=.117; FMD: b=-.025, p=.895) WIQ speed (PWV: b=.320, p=.181; FMD: b=-.028, p=.497), WIQ stairs (PWV: b=.256, p=.204; FMD: b=-.228, p=.230), 4-meter usual walk (PWV: b=-.421, p=.107; FMD: b=-.338, p=.112), 4-meter fast walk (PWV: b=-.496, p=.063; FMD: b=-.371, p=.086) and vascular function were found.ConclusionsIn symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes.

KW - peripheral arterial disease; vascular function; functional capacity; six-minute walk test.

KW - six-minute walk test

KW - functional capacity

KW - vascular function

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U2 - 10.1016/j.avsg.2021.06.011

DO - 10.1016/j.avsg.2021.06.011

M3 - Article

C2 - 34455045

SN - 0890-5096

VL - 77

SP - 31

EP - 37

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

ER -