The objective of this study was to develop an optimum artificial neural network (ANN) capable of predicting the direction and magnitude of the moisture flux through wood under nonisothermal steady-state diffusion. A comparison between experimental measurements and the predicted values of three mathematical models reported in the literature and of the proposed neural network is presented and discussed. When developing the ANN model, several configurations were evaluated. The optimal ANN model was found to be a network with six neurons in one hidden layer. This well-trained network correlated the forecasted to the experimental data with low-level errors compared to previously developed models and also predicted the flux-reversal phenomenon thus confirming that ANN modeling has a much better predictive performance. It was also shown that the numbers of the training data were linked to the performance of the network during estimation. However, the powerful predictive capacity of this modeling method was still supported although a limited experimental data set was trained.