Assessing the energy performance of existing residential buildings (ERB) has been identified as key to improving building energy efficiency and reducing associated greenhouse gas emissions in Canada. However, identifying optimal retrofit packages requires a significant amount of knowledge of building energy modelling, and it is a time-consuming and laborious process. This paper proposed a data-driven framework that combines machine learning, multi-objective optimization, and multi-criteria decision-making techniques to evaluate the energy performance of ERB and thereby formulate optimal retrofit plans. First, an artificial neural network (ANN) was developed to predict the energy performance of a wide range of retrofit packages. A genetic algorithm was employed to determine the best structure and hyperparameters of the ANN model. Then, the energy consumption results were integrated with environmental and economic impact data to evaluate the environmental and economic performance of retrofit packages and thereby identify Pareto optimal solutions. Finally, a multi-criteria decision-making method was used to select the best retrofit packages among the optimal solutions. The proposed framework was validated using data on a typical residential building in British Columbia, Canada. The results indicated that this framework could effectively predict building energy performance and help decision-makers to make an optimal decision when choosing retrofit packages.