Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3–ascorbate complex

Alfred Thumser, Aswir Abd Rashed, Paul Sharp, John Lodge

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

It has been well documented that ascorbate enhances iron uptake, with a proposed mechanism based on reduction to the more absorbable ferrous form. We have performed a study on the effects of ascorbate on ferric iron uptake in the human epithelial Caco-2 cell-line. Ascorbate increased uptake in a concentration-dependent manner with a significant difference between iron uptake and reduction. Uptake kinetics are characteristic of a non-essential activator and the formation of an Fe(3+)-ascorbate complex. This investigation provides evidence that ascorbate enhances the apical uptake of ferric iron into Caco-2 cells through the formation of a Fe(3+)-ascorbate complex.
Original languageEnglish
Pages (from-to)281-285
JournalFood Chemistry
Volume123
Issue number2
DOIs
Publication statusPublished - Nov 2010

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