Abstract
BACKGROUND: The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown.
AIMS: To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy.
METHOD: Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38).
RESULTS: Infants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group.
CONCLUSIONS: In utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.
| Original language | English |
|---|---|
| Pages (from-to) | 333-7 |
| Number of pages | 5 |
| Journal | British Journal of Psychiatry |
| Volume | 192 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2008 |
| Externally published | Yes |
Keywords
- Adult
- Antipsychotic Agents/adverse effects
- Benzodiazepines/adverse effects
- Birth Weight/drug effects
- Clozapine/adverse effects
- Female
- Fetal Macrosomia/chemically induced
- Gestational Age
- Humans
- Infant, Newborn
- Male
- Mental Disorders/drug therapy
- Olanzapine
- Pregnancy
- Pregnancy Complications/drug therapy
- Prenatal Exposure Delayed Effects/chemically induced
- Prospective Studies
- Statistics, Nonparametric