Black phosphorus–polypyrrole nanocomposites for high-performance photothermal cancer therapy

Chengkang Su; Huiqing Zhong; Haolin Chen; Yanxian Guo; Zhouyi Guo; Deqiu Huang; Wen Zhang; Qiang Wu; Biwen Yang; Zhiming Liu

doi:10.1039/C9NJ01249D

Black phosphorus–polypyrrole nanocomposites for high-performance photothermal cancer therapy

Chengkang Su, Huiqing Zhong, Haolin Chen, Yanxian Guo, Zhouyi Guo, Deqiu Huang, Wen Zhang, Qiang Wu, Biwen Yang, Zhiming Liu

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19 Citations (Scopus)

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Abstract

The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo.

Original language	English
Pages (from-to)	8620-8626
Number of pages	7
Journal	New Journal of Chemistry
Volume	43
Issue number	22
DOIs	https://doi.org/10.1039/C9NJ01249D
Publication status	Published - 6 May 2019

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Su et al - Black phosphorus nanosheet-polypyrrole nanocomposites AAMAccepted author manuscript, 2.09 MB

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title = "Black phosphorus–polypyrrole nanocomposites for high-performance photothermal cancer therapy",

abstract = "The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo.",

author = "Chengkang Su and Huiqing Zhong and Haolin Chen and Yanxian Guo and Zhouyi Guo and Deqiu Huang and Wen Zhang and Qiang Wu and Biwen Yang and Zhiming Liu",

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language = "English",

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TY - JOUR

T1 - Black phosphorus–polypyrrole nanocomposites for high-performance photothermal cancer therapy

AU - Su, Chengkang

AU - Zhong, Huiqing

AU - Chen, Haolin

AU - Guo, Yanxian

AU - Guo, Zhouyi

AU - Huang, Deqiu

AU - Zhang, Wen

AU - Wu, Qiang

AU - Yang, Biwen

AU - Liu, Zhiming

PY - 2019/5/6

Y1 - 2019/5/6

N2 - The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo.

AB - The favorable biocompatibility, biodegradability and broadband absorption in the ultraviolet to near-infrared (NIR) region have made black phosphorus (BP) a new generation two-dimensional nanomaterial with great potential for photothermal therapy (PTT). However, an appropriate but not low dosage of nanoagent is required to achieve the satisfactory therapeutic effect in BP-based NIR PTT, due to the decreasing light absorption of BP in the NIR region. In this work, nanohybrids composed of BP nanosheets and several polypyrrole (PPy) nanoparticles attached to them (BP/PPy NSs) are fabricated for high-performance NIR PTT, benefiting from the superimposed NIR absorption characteristics of the two components. The nanocomposites exhibit irregular, speckled and flake-like morphologies with good biocompatibility and superior NIR photothermal transduction efficiency compared with that of the bare nanosheets. The utilization of BP/PPy NSs as novel nanotherapeutic agent for enhanced NIR photothermal cancer therapy is accomplished in vitro and in vivo.

UR - https://www.scopus.com/pages/publications/85066932479

U2 - 10.1039/C9NJ01249D

DO - 10.1039/C9NJ01249D

M3 - Article

SN - 1144-0546

VL - 43

SP - 8620

EP - 8626

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 22

ER -

Black phosphorus–polypyrrole nanocomposites for high-performance photothermal cancer therapy

Abstract

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