Burnout is a multidimensional syndrome that occurs primarily in professions where practitioners are subjected to stress associated with direct interpersonal contact with clients. Previous research indicates that working as a real estate broker is a particularly stressful form of work. Considering the potentially harmful effect of burnout on real estate brokers, resulting in a range of negative impacts, it is important to identify those factors emanating from either the individual or their work environment that contribute to this syndrome. The paper presents a study that used a questionnaire survey to determine the individual demographics, work and intrapersonal characteristics that affect burnout in real estate brokers. A sample of 305 real estate brokers was obtained in Western Australia. Hierarchical regression was then employed to identify predictors of burnout (i.e. emotional exhaustion, depersonalisation, and personal accomplishment) and sense of coherence (SOC). The analysis revealed the following: emotional exhaustion was associated with lower age, higher numbers of hours worked, and lower SOC; higher depersonalisation was associated with lower age and SOC; higher personal accomplishment was associated with a greater number of visits to clients per week, the presence of postgraduate qualification and a high SOC. The results provide insight to guide health promotion for real estate brokers so as to enhance their psychological and physical well-being, thus making a contribution to improving their overall performance levels and effectiveness.