Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Claudia Hohmann, Kathrin Schneider, Christina Bruntner, Elisabeth Irran, Graeme Nicholson, Alan Bull, Amanda Jones, Roselyn Brown, James Stach, Michael Goodfellow, Winfried Beil, Marco Krämer, Johannes Imhoff, Roderich Süssmuth, Hans-Peter Fiedler

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase
Original languageEnglish
Pages (from-to)99-104
JournalJournal of Antibiotics
Volume62
DOIs
Publication statusPublished - Feb 2009

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