Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Claudia Hohmann; Kathrin Schneider; Christina Bruntner; Elisabeth Irran; Graeme Nicholson; Alan Bull; Amanda Jones; Roselyn Brown; James Stach; Michael Goodfellow; Winfried Beil; Marco Krämer; Johannes Imhoff; Roderich Süssmuth; Hans-Peter Fiedler

doi:10.1038/ja.2008.24

Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Claudia Hohmann, Kathrin Schneider, Christina Bruntner, Elisabeth Irran, Graeme Nicholson, Alan Bull, Amanda Jones, Roselyn Brown, James Stach, Michael Goodfellow, Winfried Beil, Marco Krämer, Johannes Imhoff, Roderich Süssmuth, Hans-Peter Fiedler

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

164 Citations (Scopus)

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase

Original language	English
Pages (from-to)	99-104
Journal	Journal of Antibiotics
Volume	62
DOIs	https://doi.org/10.1038/ja.2008.24
Publication status	Published - Feb 2009

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10.1038/ja.2008.24

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Hohmann, C., Schneider, K., Bruntner, C., Irran, E., Nicholson, G., Bull, A., Jones, A., Brown, R., Stach, J., Goodfellow, M., Beil, W., Krämer, M., Imhoff, J., Süssmuth, R., & Fiedler, H.-P. (2009). Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937. Journal of Antibiotics, 62, 99-104. https://doi.org/10.1038/ja.2008.24

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title = "Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937",

abstract = "Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase",

author = "Claudia Hohmann and Kathrin Schneider and Christina Bruntner and Elisabeth Irran and Graeme Nicholson and Alan Bull and Amanda Jones and Roselyn Brown and James Stach and Michael Goodfellow and Winfried Beil and Marco Kr{\"a}mer and Johannes Imhoff and Roderich S{\"u}ssmuth and Hans-Peter Fiedler",

year = "2009",

month = feb,

doi = "10.1038/ja.2008.24",

language = "English",

volume = "62",

pages = "99--104",

journal = "Journal of Antibiotics",

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Hohmann, C, Schneider, K, Bruntner, C, Irran, E, Nicholson, G, Bull, A, Jones, A, Brown, R, Stach, J, Goodfellow, M, Beil, W, Krämer, M, Imhoff, J, Süssmuth, R & Fiedler, H-P 2009, 'Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937', Journal of Antibiotics, vol. 62, pp. 99-104. https://doi.org/10.1038/ja.2008.24

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T1 - Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

AU - Hohmann, Claudia

AU - Schneider, Kathrin

AU - Bruntner, Christina

AU - Irran, Elisabeth

AU - Nicholson, Graeme

AU - Bull, Alan

AU - Jones, Amanda

AU - Brown, Roselyn

AU - Stach, James

AU - Goodfellow, Michael

AU - Beil, Winfried

AU - Krämer, Marco

AU - Imhoff, Johannes

AU - Süssmuth, Roderich

AU - Fiedler, Hans-Peter

PY - 2009/2

Y1 - 2009/2

N2 - Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase

AB - Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase

U2 - 10.1038/ja.2008.24

DO - 10.1038/ja.2008.24

M3 - Article

SN - 0021-8820

VL - 62

SP - 99

EP - 104

JO - Journal of Antibiotics

JF - Journal of Antibiotics

ER -

Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Abstract

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