Cancer prevention through weight control-where are we in 2020?

UK NIHR Cancer and Nutrition Collaboration (Population Health Stream), Annie S Anderson*, Andrew G Renehan, John M Saxton, Joshua Bell, Janet Cade, Amanda J Cross, Angela King, Elio Riboli, Falko Sniehotta, Shaun Treweek, Richard M Martin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
12 Downloads (Pure)


Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.
Original languageEnglish
Pages (from-to)1049-1056
Number of pages8
JournalBritish Journal of Cancer
Issue number6
Early online date25 Nov 2020
Publication statusPublished - 16 Mar 2021


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