TY - JOUR
T1 - Capturing Multicellular System Designs Using Synthetic Biology Open Language (SBOL)
AU - Brown, Bradley
AU - Bartley, Bryan
AU - Beal, Jacob
AU - Bird, Jasmine E
AU - Goñi Moreno, Ángel
AU - McLaughlin, James Alastair
AU - Misirli, Goksel
AU - Roehner, Nicholas
AU - Skelton, David James
AU - Poh, Chueh Loo
AU - Ofiteru, Irina Dana
AU - James, Katherine
AU - Wipat, Anil
PY - 2020/7/31
Y1 - 2020/7/31
N2 - Synthetic biology aims to develop novel biological systems and increase their reproducibility using engineering principles such as standardization and modularization. It is important that these systems can be represented and shared in a standard way to ensure they can be easily understood, reproduced, and utilized by other researchers. The Synthetic Biology Open Language (SBOL) is a data standard for sharing biological designs and information about their implementation and characterization. Previously, this standard has only been used to represent designs in systems where the same design is implemented in every cell; however, there is also much interest in multicellular systems, in which designs involve a mixture of different types of cells with differing genotype and phenotype. Here, we show how the SBOL standard can be used to represent multicellular systems, and, hence, how researchers can better share designs with the community and reliably document intended system functionality.
AB - Synthetic biology aims to develop novel biological systems and increase their reproducibility using engineering principles such as standardization and modularization. It is important that these systems can be represented and shared in a standard way to ensure they can be easily understood, reproduced, and utilized by other researchers. The Synthetic Biology Open Language (SBOL) is a data standard for sharing biological designs and information about their implementation and characterization. Previously, this standard has only been used to represent designs in systems where the same design is implemented in every cell; however, there is also much interest in multicellular systems, in which designs involve a mixture of different types of cells with differing genotype and phenotype. Here, we show how the SBOL standard can be used to represent multicellular systems, and, hence, how researchers can better share designs with the community and reliably document intended system functionality.
U2 - 10.1021/acssynbio.0c00176
DO - 10.1021/acssynbio.0c00176
M3 - Article
C2 - 32786354
VL - 9
SP - 2410
EP - 2417
JO - ACS Synthetic Biology
JF - ACS Synthetic Biology
SN - 2161-5063
IS - 9
ER -