Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries

Aimee L. Drane, Rebeca Atencia, Stephen-Mark Cooper, Pablo Rodriguez, Carlos Sanchez, Sarah Simcox, Yedra Feltrer, Bruce Peck, Jaclyn Eng, Sophie Moittie, Steve Unwin, Glyn Howatson, David Oxborough, Mike R. Stembridge, Rob E. Shave

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

OBJECTIVE To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries. ANIMALS 290 wild-born captive chimpanzees. PROCEDURES Physical and echocardiographic examinations were performed on anesthetized chimpanzees in 3 sanctuaries in Africa between October 2013 and May 2017. Results were evaluated across age groups and between sexes, and potential differences were assessed with multiple 1-way independent Kruskal-Wallis tests. RESULTS Results indicated that left ventricular diastolic and systolic function declined at a younger age in males than in females. Although differences in right ventricular diastolic function were not identified among age groups, right ventricular systolic function was lower in adult chimpanzees (> 12 years old), compared with subadult (8 to 12 years old) and juvenile (5 to 7 years old) chimpanzees. In addition, male subadult and adult chimpanzees had larger cardiac wall dimensions and chamber volumes than did their female counterparts. CONCLUSIONS AND CLINICAL RELEVANCE Results of the present study provided useful reference intervals for cardiac structure and function in captive chimpanzees categorized on the basis of age and sex; however, further research is warranted to examine isolated and combined impacts of blood pressure, age, body weight, and anesthetic agents on cardiac structure and function in chimpanzees.
Original languageEnglish
Pages (from-to)547-557
Number of pages11
JournalAmerican Journal of Veterinary Research
Volume80
Issue number6
Early online date29 May 2019
DOIs
Publication statusPublished - 1 Jun 2019

Fingerprint Dive into the research topics of 'Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries'. Together they form a unique fingerprint.

Cite this